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Docusate-Based Ionic Liquids of Anthelmintic Benzimidazoles Show Improved Pharmaceutical Processability, Lipid Solubility, and in Vitro Activity against Cryptococcus neoformans.
Sutar Y, Fulton SR, Paul S, Altamirano S, Mhatre S, Saeed H, Patel P, Mallick S, Bhat R, Patravale VB, Chauhan H, Nielsen K, Date AA. Sutar Y, et al. ACS Infect Dis. 2021 Sep 10;7(9):2637-2649. doi: 10.1021/acsinfecdis.1c00063. Epub 2021 Sep 1. ACS Infect Dis. 2021. PMID: 34467755 Free PMC article.
A titanic drug resistance threat in Cryptococcus neoformans.
Zafar H, Altamirano S, Ballou ER, Nielsen K. Zafar H, et al. Curr Opin Microbiol. 2019 Dec;52:158-164. doi: 10.1016/j.mib.2019.11.001. Epub 2019 Nov 22. Curr Opin Microbiol. 2019. PMID: 31765991 Free PMC article. Review.
The Mouse Inhalation Model of Cryptococcus neoformans Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess Differential Virulence.
Mukaremera L, McDonald TR, Nielsen JN, Molenaar CJ, Akampurira A, Schutz C, Taseera K, Muzoora C, Meintjes G, Meya DB, Boulware DR, Nielsen K. Mukaremera L, et al. Infect Immun. 2019 Apr 23;87(5):e00046-19. doi: 10.1128/IAI.00046-19. Print 2019 Mar. Infect Immun. 2019. PMID: 30833336 Free PMC article.
Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.
Hommel B, Mukaremera L, Cordero RJB, Coelho C, Desjardins CA, Sturny-Leclère A, Janbon G, Perfect JR, Fraser JA, Casadevall A, Cuomo CA, Dromer F, Nielsen K, Alanio A. Hommel B, et al. PLoS Pathog. 2018 May 18;14(5):e1006982. doi: 10.1371/journal.ppat.1006982. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29775480 Free PMC article.