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PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion.
Hope JL, Otero DC, Bae EA, Stairiker CJ, Palete AB, Faso HA, Lin M, Henriquez ML, Roy S, Seo H, Lei X, Wang ES, Chow S, Tinoco R, Daniels GA, Yip K, Campos AR, Yin J, Adams PD, Rao A, Bradley LM. Hope JL, et al. Cell Rep. 2023 May 30;42(5):112436. doi: 10.1016/j.celrep.2023.112436. Epub 2023 Apr 26. Cell Rep. 2023. PMID: 37115668 Free PMC article.
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice.
Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Kaufman RJ, Bosenberg M, Goding CR, Baaten B, Levesque MP, Dummer R, Brown K, Merlino G, Ruppin E, Flaherty K, Ramer-Tait A, Long T, Peterson SN, Bradley LM, Ronai ZA. Li Y, et al. Nat Commun. 2019 Apr 2;10(1):1492. doi: 10.1038/s41467-019-09525-y. Nat Commun. 2019. PMID: 30940817 Free PMC article.
Targeting the PSGL-1 pathway for immune modulation.
Tinoco R, Bradley LM. Tinoco R, et al. Immunotherapy. 2017 Sep;9(10):785-788. doi: 10.2217/imt-2017-0078. Immunotherapy. 2017. PMID: 28877633 Free PMC article. No abstract available.
PSGL-1: A New Player in the Immune Checkpoint Landscape.
Tinoco R, Otero DC, Takahashi AA, Bradley LM. Tinoco R, et al. Trends Immunol. 2017 May;38(5):323-335. doi: 10.1016/j.it.2017.02.002. Epub 2017 Mar 2. Trends Immunol. 2017. PMID: 28262471 Free PMC article. Review.