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Different Munc18 proteins mediate baseline and stimulated airway mucin secretion.
Jaramillo AM, Piccotti L, Velasco WV, Delgado ASH, Azzegagh Z, Chung F, Nazeer U, Farooq J, Brenner J, Parker-Thornburg J, Scott BL, Evans CM, Adachi R, Burns AR, Kreda SM, Tuvim MJ, Dickey BF. Jaramillo AM, et al. JCI Insight. 2019 Mar 21;4(6):e124815. doi: 10.1172/jci.insight.124815. eCollection 2019 Mar 21. JCI Insight. 2019. PMID: 30721150 Free PMC article.
Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated exocytosis, where it plays a primary role mediating compound exocytosis.
Sanchez E, Gonzalez EA, Moreno DS, Cardenas RA, Ramos MA, Davalos AJ, Manllo J, Rodarte AI, Petrova Y, Moreira DC, Chavez MA, Tortoriello A, Lara A, Gutierrez BA, Burns AR, Heidelberger R, Adachi R. Sanchez E, et al. J Biol Chem. 2019 Mar 1;294(9):3012-3023. doi: 10.1074/jbc.RA118.005532. Epub 2018 Dec 18. J Biol Chem. 2019. PMID: 30563839 Free PMC article.
Munc13 proteins control regulated exocytosis in mast cells.
Rodarte EM, Ramos MA, Davalos AJ, Moreira DC, Moreno DS, Cardenas EI, Rodarte AI, Petrova Y, Molina S, Rendon LE, Sanchez E, Breaux K, Tortoriello A, Manllo J, Gonzalez EA, Tuvim MJ, Dickey BF, Burns AR, Heidelberger R, Adachi R. Rodarte EM, et al. J Biol Chem. 2018 Jan 5;293(1):345-358. doi: 10.1074/jbc.M117.816884. Epub 2017 Nov 15. J Biol Chem. 2018. PMID: 29141910 Free PMC article.