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Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS. Abskharon R, et al. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2300258120. doi: 10.1073/pnas.2300258120. Epub 2023 Oct 6. Proc Natl Acad Sci U S A. 2023. PMID: 37801475 Free PMC article.
De novo designed protein inhibitors of amyloid aggregation and seeding.
Murray KA, Hu CJ, Griner SL, Pan H, Bowler JT, Abskharon R, Rosenberg GM, Cheng X, Seidler PM, Eisenberg DS. Murray KA, et al. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206240119. doi: 10.1073/pnas.2206240119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969734 Free PMC article.
13 results