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2021 2
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2023 5
2024 1

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Page 1
Distinct secretomes in p16- and p21- positive senescent cells across tissues.
Saul D, Jurk D, Doolittle ML, Kosinsky RL, Monroe DG, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Khosla S, Passos JF. Saul D, et al. bioRxiv [Preprint]. 2023 Dec 5:2023.12.05.569858. doi: 10.1101/2023.12.05.569858. bioRxiv. 2023. PMID: 38106149 Free PMC article. Preprint.
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study.
Habiballa L, Hruby A, Granic A, Dodds RM, Hillman SJ, Jurk D, Passos JF, Sayer AA. Habiballa L, et al. Geroscience. 2024 Feb;46(1):1141-1158. doi: 10.1007/s11357-023-00869-4. Epub 2023 Jul 11. Geroscience. 2024. PMID: 37434081 Free PMC article.
Telomere dysfunction in chronic liver disease: The link from aging.
Penrice DD, Jalan-Sakrikar N, Jurk D, Passos JF, Simonetto DA. Penrice DD, et al. Hepatology. 2023 Apr 28:10.1097/HEP.0000000000000426. doi: 10.1097/HEP.0000000000000426. Online ahead of print. Hepatology. 2023. PMID: 37102475 No abstract available.
A chronic wound model to investigate skin cellular senescence.
Wyles SP, Dashti P, Pirtskhalava T, Tekin B, Inman C, Gomez LS, Lagnado AB, Prata L, Jurk D, Passos JF, Tchkonia T, Kirkland JL. Wyles SP, et al. Aging (Albany NY). 2023 Apr 21;15(8):2852-2862. doi: 10.18632/aging.204667. Epub 2023 Apr 21. Aging (Albany NY). 2023. PMID: 37086260 Free PMC article.
Telomere dysfunction in ageing and age-related diseases.
Rossiello F, Jurk D, Passos JF, d'Adda di Fagagna F. Rossiello F, et al. Nat Cell Biol. 2022 Feb;24(2):135-147. doi: 10.1038/s41556-022-00842-x. Epub 2022 Feb 14. Nat Cell Biol. 2022. PMID: 35165420 Free PMC article. Review.
Senolytic drugs: Beyond the promise and the hype.
Jurk D, Passos JF. Jurk D, et al. Mech Ageing Dev. 2022 Mar;202:111631. doi: 10.1016/j.mad.2022.111631. Epub 2022 Jan 12. Mech Ageing Dev. 2022. PMID: 35032547 Free PMC article. No abstract available.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Vizioli MG, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF. Lagnado A, et al. EMBO J. 2021 May 3;40(9):e106048. doi: 10.15252/embj.2020106048. Epub 2021 Mar 25. EMBO J. 2021. PMID: 33764576 Free PMC article.
Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.
Ogrodnik M, Evans SA, Fielder E, Victorelli S, Kruger P, Salmonowicz H, Weigand BM, Patel AD, Pirtskhalava T, Inman CL, Johnson KO, Dickinson SL, Rocha A, Schafer MJ, Zhu Y, Allison DB, von Zglinicki T, LeBrasseur NK, Tchkonia T, Neretti N, Passos JF, Kirkland JL, Jurk D. Ogrodnik M, et al. Aging Cell. 2021 Feb;20(2):e13296. doi: 10.1111/acel.13296. Epub 2021 Jan 20. Aging Cell. 2021. PMID: 33470505 Free PMC article.