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2018 1
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Page 1
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D, Kanaan NM, Gan L, Condello C, Swaney DL, Kampmann M. Samelson AJ, et al. bioRxiv [Preprint]. 2023 Jun 26:2023.06.16.545386. doi: 10.1101/2023.06.16.545386. bioRxiv. 2023. PMID: 37398204 Free PMC article. Preprint.
Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion.
Krause GJ, Diaz A, Jafari M, Khawaja RR, Agullo-Pascual E, Santiago-Fernández O, Richards AL, Chen KH, Dmitriev P, Sun Y, See SK, Abdelmohsen K, Mazan-Mamczarz K, Krogan NJ, Gorospe M, Swaney DL, Sidoli S, Bravo-Cordero JJ, Kampmann M, Cuervo AM. Krause GJ, et al. Aging Cell. 2022 Oct;21(10):e13713. doi: 10.1111/acel.13713. Epub 2022 Sep 18. Aging Cell. 2022. PMID: 36116133 Free PMC article.
Patterns of neuronal Rhes as a novel hallmark of tauopathies.
Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. Ehrenberg AJ, et al. Acta Neuropathol. 2021 May;141(5):651-666. doi: 10.1007/s00401-021-02279-2. Epub 2021 Mar 7. Acta Neuropathol. 2021. PMID: 33677647 Free PMC article.
LRP1 is a master regulator of tau uptake and spread.
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. Rauch JN, et al. Nature. 2020 Apr;580(7803):381-385. doi: 10.1038/s41586-020-2156-5. Epub 2020 Apr 1. Nature. 2020. PMID: 32296178 Free PMC article.
14 results