R01 AG040092/AG/NIA NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2013	2
2015	3
2016	2
2017	2
2018	2
2019	1
2020	3
2021	2
2024	0

1

Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice.

Hoffmann T, Rahfeld JU, Schenk M, Ponath F, Makioka K, Hutter-Paier B, Lues I, Lemere CA, Schilling S. Hoffmann T, et al. Int J Mol Sci. 2021 Oct 30;22(21):11791. doi: 10.3390/ijms222111791. Int J Mol Sci. 2021. PMID: 34769222 Free PMC article.

2

Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells.

Sun T, Shi Q, Zhang Y, Power C, Hoesch C, Antonelli S, Schroeder MK, Caldarone BJ, Taudte N, Schenk M, Hettmann T, Schilling S, McDannold NJ, Lemere CA. Sun T, et al. J Control Release. 2021 Aug 10;336:443-456. doi: 10.1016/j.jconrel.2021.06.037. Epub 2021 Jun 26. J Control Release. 2021. PMID: 34186148 Free PMC article.

3

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models.

Kumar S, Lemere CA, Walter J. Kumar S, et al. Acta Neuropathol Commun. 2020 Jul 29;8(1):118. doi: 10.1186/s40478-020-00959-w. Acta Neuropathol Commun. 2020. PMID: 32727580 Free PMC article.

4

Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer's disease with reduced complement activation.

Hettmann T, Gillies SD, Kleinschmidt M, Piechotta A, Makioka K, Lemere CA, Schilling S, Rahfeld JU, Lues I. Hettmann T, et al. Sci Rep. 2020 Feb 24;10(1):3294. doi: 10.1038/s41598-020-60319-5. Sci Rep. 2020. PMID: 32094456 Free PMC article.

5

Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice.

Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O'Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA. Crehan H, et al. Alzheimers Res Ther. 2020 Jan 13;12(1):12. doi: 10.1186/s13195-019-0579-8. Alzheimers Res Ther. 2020. PMID: 31931873 Free PMC article.

6

Active Amyloid-β Vaccination Results in Epigenetic Changes in the Hippocampus of an Alzheimer's Disease-Like Mouse Model.

Lardenoije R, van den Hove DLA, Jung SE, Havermans M, Blackburn P, Liu B, Rutten BPF, Lemere CA. Lardenoije R, et al. Curr Alzheimer Res. 2019;16(9):861-870. doi: 10.2174/1567205016666190827122009. Curr Alzheimer Res. 2019. PMID: 31453788

7

Microglial signatures and their role in health and disease.

Butovsky O, Weiner HL. Butovsky O, et al. Nat Rev Neurosci. 2018 Oct;19(10):622-635. doi: 10.1038/s41583-018-0057-5. Nat Rev Neurosci. 2018. PMID: 30206328 Free PMC article. Review.

8

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease.

Lardenoije R, van den Hove DLA, Havermans M, van Casteren A, Le KX, Palmour R, Lemere CA, Rutten BPF. Lardenoije R, et al. Mol Cell Neurosci. 2018 Jan;86:1-15. doi: 10.1016/j.mcn.2017.11.002. Epub 2017 Nov 4. Mol Cell Neurosci. 2018. PMID: 29113959 Free PMC article.

9

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. Krasemann S, et al. Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008. Immunity. 2017. PMID: 28930663 Free PMC article.

10

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges.

Cynis H, Frost JL, Crehan H, Lemere CA. Cynis H, et al. Mol Neurodegener. 2016 Jun 30;11(1):48. doi: 10.1186/s13024-016-0115-2. Mol Neurodegener. 2016. PMID: 27363697 Free PMC article. Review.

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