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Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex.
J Biol Chem. 2019 Feb 8;294(6):2036-2045. doi: 10.1074/jbc.RA118.006290. Epub 2018 Dec 17.
J Biol Chem. 2019.
PMID: 30559296
Free PMC article.
Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.
Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, Bogyo M, Steinmetz LM, Radhakrishnan SK, Bertozzi CR.
Tomlin FM, et al.
ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. doi: 10.1021/acscentsci.7b00224. Epub 2017 Oct 25.
ACS Cent Sci. 2017.
PMID: 29202016
Free PMC article.
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Nrf1 can be processed and activated in a proteasome-independent manner.
Vangala JR, Sotzny F, Krüger E, Deshaies RJ, Radhakrishnan SK.
Vangala JR, et al.
Curr Biol. 2016 Sep 26;26(18):R834-R835. doi: 10.1016/j.cub.2016.08.008.
Curr Biol. 2016.
PMID: 27676297
Free PMC article.
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