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Novel engineered TRAIL-based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance.
Rozga P, Kloska D, Pawlak S, Teska-Kaminska M, Galazka M, Bukato K, Pieczykolan A, Jaworski A, Molga-Kaczmarska A, Kopacz A, Badyra B, Kachamakova-Trojanowska N, Zolnierkiewicz O, Targosz-Korecka M, Poleszak K, Szymanik M, Zerek B, Pieczykolan J, Jozkowicz A, Grochot-Przeczek A. Rozga P, et al. Int J Cancer. 2020 Aug 15;147(4):1117-1130. doi: 10.1002/ijc.32845. Epub 2020 Jan 24. Int J Cancer. 2020. PMID: 31863596 Free article.
AD-O53.2--a novel recombinant fusion protein combining the activities of TRAIL/Apo2L and Smac/Diablo, overcomes resistance of human cancer cells to TRAIL/Apo2L.
Pieczykolan JS, Kubiński K, Masłyk M, Pawlak SD, Pieczykolan A, Rózga PK, Szymanik M, Gałązka M, Teska-Kamińska M, Żerek B, Bukato K, Poleszak K, Jaworski A, Strożek W, Świder R, Zieliński R. Pieczykolan JS, et al. Among authors: rozga pk. Invest New Drugs. 2014 Dec;32(6):1155-66. doi: 10.1007/s10637-014-0153-y. Epub 2014 Sep 4. Invest New Drugs. 2014. PMID: 25182378