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Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Adams R, Burnley RJ, Valenzano CR, Qureshi O, Doyle C, Lumb S, Del Carmen Lopez M, Griffin R, McMillan D, Taylor RD, Meier C, Mori P, Griffin LM, Wernery U, Kinne J, Rapecki S, Baker TS, Lawson AD, Wright M, Ettorre A. Adams R, et al. Among authors: qureshi o. Sci Rep. 2017 Jan 30;7:37716. doi: 10.1038/srep37716. Sci Rep. 2017. PMID: 28134246 Free PMC article.
Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions.
Qureshi OS, Rowley TF, Junker F, Peters SJ, Crilly S, Compson J, Eddleston A, Björkelund H, Greenslade K, Parkinson M, Davies NL, Griffin R, Pither TL, Cain K, Christodoulou L, Staelens L, Ward E, Tibbitts J, Kiessling A, Smith B, Brennan FR, Malmqvist M, Fallah-Arani F, Humphreys DP. Qureshi OS, et al. Sci Rep. 2017 Dec 6;7(1):17049. doi: 10.1038/s41598-017-17255-8. Sci Rep. 2017. PMID: 29213127 Free PMC article.
Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration.
Smith B, Kiessling A, Lledo-Garcia R, Dixon KL, Christodoulou L, Catley MC, Atherfold P, D'Hooghe LE, Finney H, Greenslade K, Hailu H, Kevorkian L, Lightwood D, Meier C, Munro R, Qureshi O, Sarkar K, Shaw SP, Tewari R, Turner A, Tyson K, West S, Shaw S, Brennan FR. Smith B, et al. Among authors: qureshi o. MAbs. 2018 Oct;10(7):1111-1130. doi: 10.1080/19420862.2018.1505464. Epub 2018 Sep 12. MAbs. 2018. PMID: 30130439 Free PMC article.
Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation.
Roberts A, Bentley L, Tang T, Stewart F, Pallini C, Juvvanapudi J, Wallace GR, Cooper AJ, Scott A, Thickett D, Lugg ST, Bancroft H, Hemming B, Ferris C, Langman G, Robinson A, Chapman J, Naidu B, Pinkney T, Taylor GS, Brock K, Stamataki Z, Brady CA, Curnow SJ, Gordon J, Qureshi O, Barnes NM. Roberts A, et al. Among authors: qureshi o. Sci Rep. 2021 Feb 17;11(1):4030. doi: 10.1038/s41598-021-83612-3. Sci Rep. 2021. PMID: 33597595 Free PMC article.
119 results