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Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity.
Quotti Tubi L, Gurrieri C, Brancalion A, Bonaldi L, Bertorelle R, Manni S, Pavan L, Lessi F, Zambello R, Trentin L, Adami F, Ruzzene M, Pinna LA, Semenzato G, Piazza F. Quotti Tubi L, et al. J Hematol Oncol. 2013 Oct 12;6:78. doi: 10.1186/1756-8722-6-78. J Hematol Oncol. 2013. PMID: 24283803 Free PMC article.
Protein kinase CK2 regulates AKT, NF-κB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia.
Quotti Tubi L, Canovas Nunes S, Brancalion A, Doriguzzi Breatta E, Manni S, Mandato E, Zaffino F, Macaccaro P, Carrino M, Gianesin K, Trentin L, Binotto G, Zambello R, Semenzato G, Gurrieri C, Piazza F. Quotti Tubi L, et al. Leukemia. 2017 Feb;31(2):292-300. doi: 10.1038/leu.2016.209. Epub 2016 Aug 1. Leukemia. 2017. PMID: 27479180
Prosurvival autophagy is regulated by protein kinase CK1 alpha in multiple myeloma.
Carrino M, Quotti Tubi L, Fregnani A, Canovas Nunes S, Barilà G, Trentin L, Zambello R, Semenzato G, Manni S, Piazza F. Carrino M, et al. Among authors: quotti tubi l. Cell Death Discov. 2019 May 21;5:98. doi: 10.1038/s41420-019-0179-1. eCollection 2019. Cell Death Discov. 2019. PMID: 31123604 Free PMC article.
Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2.
Spinello Z, Fregnani A, Quotti Tubi L, Trentin L, Piazza F, Manni S. Spinello Z, et al. Among authors: quotti tubi l. Int J Mol Sci. 2021 Apr 2;22(7):3716. doi: 10.3390/ijms22073716. Int J Mol Sci. 2021. PMID: 33918307 Free PMC article. Review.
Protein Kinase CK1α Sustains B-Cell Receptor Signaling in Mantle Cell Lymphoma.
Manni S, Fregnani A, Quotti Tubi L, Spinello Z, Carraro M, Scapinello G, Visentin A, Barilà G, Pizzi M, Dei Tos AP, Vianello F, Zambello R, Gurrieri C, Semenzato G, Trentin L, Piazza F. Manni S, et al. Among authors: quotti tubi l. Front Oncol. 2021 Oct 14;11:733848. doi: 10.3389/fonc.2021.733848. eCollection 2021. Front Oncol. 2021. PMID: 34722279 Free PMC article.
Protein Kinase CK2 represents a new target to boost Ibrutinib and Venetoclax induced cytotoxicity in mantle cell lymphoma.
Manni S, Pesavento M, Spinello Z, Saggin L, Arjomand A, Fregnani A, Quotti Tubi L, Scapinello G, Gurrieri C, Semenzato G, Trentin L, Piazza F. Manni S, et al. Among authors: quotti tubi l. Front Cell Dev Biol. 2022 Aug 11;10:935023. doi: 10.3389/fcell.2022.935023. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36035991 Free PMC article.
CK1α/RUNX2 Axis in the Bone Marrow Microenvironment: A Novel Therapeutic Target in Multiple Myeloma.
Fregnani A, Saggin L, Gianesin K, Quotti Tubi L, Carraro M, Barilà G, Scapinello G, Bonetto G, Pesavento M, Berno T, Branca A, Gurrieri C, Zambello R, Semenzato G, Trentin L, Manni S, Piazza F. Fregnani A, et al. Among authors: quotti tubi l. Cancers (Basel). 2022 Aug 29;14(17):4173. doi: 10.3390/cancers14174173. Cancers (Basel). 2022. PMID: 36077711 Free PMC article.
CK2β-regulated signaling controls B cell differentiation and function.
Quotti Tubi L, Mandato E, Canovas Nunes S, Arjomand A, Zaffino F, Manni S, Casellato A, Macaccaro P, Vitulo N, Zumerle S, Filhol O, Boldyreff B, Siebel CW, Viola A, Valle G, Mainoldi F, Casola S, Cancila V, Gulino A, Tripodo C, Pizzi M, Dei Tos AP, Trentin L, Semenzato G, Piazza F. Quotti Tubi L, et al. Front Immunol. 2023 Jan 11;13:959138. doi: 10.3389/fimmu.2022.959138. eCollection 2022. Front Immunol. 2023. PMID: 36713383 Free PMC article.
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