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Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease.
Tumburu L, Ghosh-Choudhary S, Seifuddin FT, Barbu EA, Yang S, Ahmad MM, Wilkins LHW, Tunc I, Sivakumar I, Nichols JS, Dagur PK, Yang S, Almeida LEF, Quezado ZMN, Combs CA, Lindberg E, Bleck CKE, Zhu J, Shet AS, Chung JH, Pirooznia M, Thein SL. Tumburu L, et al. Among authors: quezado zmn. Blood. 2021 Jun 3;137(22):3116-3126. doi: 10.1182/blood.2020009063. Blood. 2021. PMID: 33661274 Free PMC article. Clinical Trial.
Nitric oxide and sickle cell disease-Is there a painful connection?
Hallmark L, Almeida LE, Kamimura S, Smith M, Quezado ZM. Hallmark L, et al. Exp Biol Med (Maywood). 2021 Feb;246(3):332-341. doi: 10.1177/1535370220976397. Epub 2020 Dec 6. Exp Biol Med (Maywood). 2021. PMID: 33517776 Free PMC article. Review.
NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice.
Vogel S, Kamimura S, Arora T, Smith ML, Almeida LEF, Combs CA, Thein SL, Quezado ZMN. Vogel S, et al. Among authors: quezado zmn. Biochem Biophys Res Commun. 2021 May 28;555:196-201. doi: 10.1016/j.bbrc.2021.03.115. Epub 2021 Apr 5. Biochem Biophys Res Commun. 2021. PMID: 33831782 Free PMC article.
Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.
Quezado ZMN, Kamimura S, Smith M, Wang X, Heaven MR, Jana S, Vogel S, Zerfas P, Combs CA, Almeida LEF, Li Q, Quezado M, Horkayne-Szakaly I, Kosinski PA, Yu S, Kapadnis U, Kung C, Dang L, Wakim P, Eaton WA, Alayash AI, Thein SL. Quezado ZMN, et al. Blood Cells Mol Dis. 2022 Jul;95:102660. doi: 10.1016/j.bcmd.2022.102660. Epub 2022 Mar 12. Blood Cells Mol Dis. 2022. PMID: 35366607 Free PMC article.
RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice.
Khaibullina A, Adjei EA, Afangbedji N, Ivanov A, Kumari N, Almeida LEF, Quezado ZMN, Nekhai S, Jerebtsova M. Khaibullina A, et al. Among authors: quezado zmn. Haematologica. 2018 May;103(5):787-798. doi: 10.3324/haematol.2017.180992. Epub 2018 Mar 8. Haematologica. 2018. PMID: 29519868 Free PMC article.
104 results