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1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.
Coviello V, Marchi B, Sartini S, Quattrini L, Marini AM, Simorini F, Taliani S, Salerno S, Orlandi P, Fioravanti A, Desidero TD, Vullo D, Da Settimo F, Supuran CT, Bocci G, La Motta C. Coviello V, et al. Among authors: quattrini l. J Med Chem. 2016 Jul 14;59(13):6547-52. doi: 10.1021/acs.jmedchem.6b00616. Epub 2016 Jun 27. J Med Chem. 2016. PMID: 27305384
Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study.
El-Sayed S, Metwally K, El-Shanawani AA, Abdel-Aziz LM, El-Rashedy AA, Soliman MES, Quattrini L, Coviello V, la Motta C. El-Sayed S, et al. Among authors: quattrini l. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4760-4764. doi: 10.1016/j.bmcl.2017.08.050. Epub 2017 Aug 24. Bioorg Med Chem Lett. 2017. PMID: 28935265
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.
La Pietra V, Sartini S, Botta L, Antonelli A, Ferrari SM, Fallahi P, Moriconi A, Coviello V, Quattrini L, Ke YY, Hsing-Pang H, Da Settimo F, Novellino E, La Motta C, Marinelli L. La Pietra V, et al. Among authors: quattrini l. Eur J Med Chem. 2018 Apr 25;150:491-505. doi: 10.1016/j.ejmech.2018.02.080. Epub 2018 Mar 2. Eur J Med Chem. 2018. PMID: 29549836
Soyasaponins from Zolfino bean as aldose reductase differential inhibitors.
Balestri F, De Leo M, Sorce C, Cappiello M, Quattrini L, Moschini R, Pineschi C, Braca A, La Motta C, Da Settimo F, Del-Corso A, Mura U. Balestri F, et al. Among authors: quattrini l. J Enzyme Inhib Med Chem. 2019 Dec;34(1):350-360. doi: 10.1080/14756366.2018.1553166. J Enzyme Inhib Med Chem. 2019. PMID: 30734590 Free PMC article.
Aldose reductase inhibitors: 2013-present.
Quattrini L, La Motta C. Quattrini L, et al. Expert Opin Ther Pat. 2019 Mar;29(3):199-213. doi: 10.1080/13543776.2019.1582646. Epub 2019 Feb 27. Expert Opin Ther Pat. 2019. PMID: 30760060 Review.
Synthesis and investigation of polyhydroxylated pyrrolidine derivatives as novel chemotypes showing dual activity as glucosidase and aldose reductase inhibitors.
Guazzelli L, D'Andrea F, Sartini S, Giorgelli F, Confini G, Quattrini L, Piano I, Nencetti S, Orlandini E, Gargini C, La Motta C. Guazzelli L, et al. Among authors: quattrini l. Bioorg Chem. 2019 Nov;92:103298. doi: 10.1016/j.bioorg.2019.103298. Epub 2019 Sep 19. Bioorg Chem. 2019. PMID: 31557624
47 results