Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.
Quan N, Sun W, Wang L, Chen X, Bogan JS, Zhou X, Cates C, Liu Q, Zheng Y, Li J.
Quan N, et al.
FASEB J. 2017 Sep;31(9):4153-4167. doi: 10.1096/fj.201700063R. Epub 2017 Jun 7.
FASEB J. 2017.
PMID: 28592638
Free PMC article.
Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults-Quan, N., Sun, W., Wang, L., Chen, X., Bogan, J. S., Zhou, X., Cates, C., Liu, Q., Zheng, Y., Li J. ...
Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK activation, alterations in substrate metabolism, and an increased sensitivit …