TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models.
Guo Y, Wei X, Yan H, Qin Y, Yan S, Liu J, Zhao Y, Jiang F, Lou H.
Guo Y, et al. Among authors: qin y.
FASEB J. 2019 Nov;33(11):12164-12174. doi: 10.1096/fj.201900992R. Epub 2019 Aug 1.
FASEB J. 2019.
PMID: 31370707
Free PMC article.
These data suggest that impairing microglial TREM2 signaling aggravates proinflammatory responses to alpha-syn and exacerbates alpha-syn-induced neurodegeneration by modulating microglial activation state.-Guo, Y., Wei, X., Yan, H., Qin, Y., Yan, S., Liu, J., …
These data suggest that impairing microglial TREM2 signaling aggravates proinflammatory responses to alpha-syn and exacerbates alpha-syn-ind …