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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors.
Chamakuri S, Lu S, Ucisik MN, Bohren KM, Chen YC, Du HC, Faver JC, Jimmidi R, Li F, Li JY, Nyshadham P, Palmer SS, Pollet J, Qin X, Ronca SE, Sankaran B, Sharma KL, Tan Z, Versteeg L, Yu Z, Matzuk MM, Palzkill T, Young DW. Chamakuri S, et al. Among authors: qin x. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2111172118. doi: 10.1073/pnas.2111172118. Proc Natl Acad Sci U S A. 2021. PMID: 34426525 Free PMC article.
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors.
Jimmidi R, Chamakuri S, Lu S, Ucisik MN, Chen PJ, Bohren KM, Moghadasi SA, Versteeg L, Nnabuife C, Li JY, Qin X, Chen YC, Faver JC, Nyshadham P, Sharma KL, Sankaran B, Judge A, Yu Z, Li F, Pollet J, Harris RS, Matzuk MM, Palzkill T, Young DW. Jimmidi R, et al. Among authors: qin x. Commun Chem. 2023 Aug 4;6(1):164. doi: 10.1038/s42004-023-00961-y. Commun Chem. 2023. PMID: 37542196 Free PMC article.
MALDI imaging mass spectrometry visualizes the distribution of antidepressant duloxetine and its major metabolites in mouse brain, liver, kidney, and spleen tissues.
Khalil SM, Qin X, Hakenjos JM, Wang J, Hu Z, Liu X, Wang J, Maletic-Savatic M, MacKenzie KR, Matzuk MM, Li F. Khalil SM, et al. Among authors: qin x. Drug Metab Dispos. 2024 Apr 24:DMD-AR-2024-001719. doi: 10.1124/dmd.124.001719. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38658163 Free article.
8,905 results