Qian S - Search Results

1

Current Research on Pro-drug Therapies for Parkinson's and Alzheimer's Disease.

Huo C, Wu L, Jiang Z, Yang J, Wang Z, Li Y, Qian S. Huo C, et al. Among authors: qian s. Med Chem. 2022;18(6):655-666. doi: 10.2174/1573406418666211130150821. Med Chem. 2022. PMID: 34847848 Review.

2

Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties.

Qian S, He T, Wang W, He Y, Zhang M, Yang L, Li G, Wang Z. Qian S, et al. Bioorg Med Chem. 2016 Dec 1;24(23):6194-6205. doi: 10.1016/j.bmc.2016.10.003. Epub 2016 Oct 6. Bioorg Med Chem. 2016. PMID: 27769672

3

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.

Yang L, Ma X, Yuan C, He Y, Li L, Fang S, Xia W, He T, Qian S, Xu Z, Li G, Wang Z. Yang L, et al. Among authors: qian s. Eur J Med Chem. 2017 Jul 7;134:230-241. doi: 10.1016/j.ejmech.2017.04.010. Epub 2017 Apr 12. Eur J Med Chem. 2017. PMID: 28415012

4

4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors.

Yang L, Chen Y, He J, Njoya EM, Chen J, Liu S, Xie C, Huang W, Wang F, Wang Z, Li Y, Qian S. Yang L, et al. Among authors: qian s. Bioorg Med Chem. 2019 Mar 15;27(6):1087-1098. doi: 10.1016/j.bmc.2019.02.014. Epub 2019 Feb 8. Bioorg Med Chem. 2019. PMID: 30773421

5

Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase.

Yang LL, Xu W, Yan J, Su HL, Yuan C, Li C, Zhang X, Yu ZJ, Yan YH, Yu Y, Chen Q, Wang Z, Li L, Qian S, Li GB. Yang LL, et al. Among authors: qian s. Medchemcomm. 2018 Dec 7;10(1):164-168. doi: 10.1039/c8md00462e. eCollection 2019 Jan 1. Medchemcomm. 2018. PMID: 30774863 Free PMC article.

6

Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.

Wang L, Li C, Chen W, Song C, Zhang X, Yang F, Wang C, Zhang Y, Qian S, Wang Z, Yang L. Wang L, et al. Among authors: qian s. Molecules. 2019 Jul 26;24(15):2724. doi: 10.3390/molecules24152724. Molecules. 2019. PMID: 31357491 Free PMC article.

7

Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy.

Yang L, Chen F, Gao C, Chen J, Li J, Liu S, Zhang Y, Wang Z, Qian S. Yang L, et al. Among authors: qian s. J Enzyme Inhib Med Chem. 2020 Dec;35(1):152-164. doi: 10.1080/14756366.2019.1690481. J Enzyme Inhib Med Chem. 2020. PMID: 31742469 Free PMC article.

8

Discovery of [1,2,4]Triazole Derivatives as New Metallo-β-Lactamase Inhibitors.

Yuan C, Yan J, Song C, Yang F, Li C, Wang C, Su H, Chen W, Wang L, Wang Z, Qian S, Yang L. Yuan C, et al. Among authors: qian s. Molecules. 2019 Dec 23;25(1):56. doi: 10.3390/molecules25010056. Molecules. 2019. PMID: 31877988 Free PMC article.

9

Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection.

Guo Y, Chen J, Ren D, Du B, Wu L, Zhang Y, Wang Z, Qian S. Guo Y, et al. Among authors: qian s. Bioorg Med Chem. 2021 Jun 15;40:116184. doi: 10.1016/j.bmc.2021.116184. Epub 2021 May 1. Bioorg Med Chem. 2021. PMID: 33971489

10

X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.

Ning XL, Li YZ, Huo C, Deng J, Gao C, Zhu KR, Wang M, Wu YX, Yu JL, Ren YL, Luo ZY, Li G, Chen Y, Wang SY, Peng C, Yang LL, Wang ZY, Wu Y, Qian S, Li GB. Ning XL, et al. Among authors: qian s. J Med Chem. 2021 Jun 24;64(12):8303-8332. doi: 10.1021/acs.jmedchem.1c00303. Epub 2021 Jun 10. J Med Chem. 2021. PMID: 34110158

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