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Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y. Liu XT, et al. Among authors: qi y. J Transl Med. 2024 Jan 10;22(1):43. doi: 10.1186/s12967-023-04830-z. J Transl Med. 2024. PMID: 38200582 Free PMC article.
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Aji G, Huang Y, Ng ML, Wang W, Lan T, Li M, Li Y, Chen Q, Li R, Yan S, Tran C, Burchfield JG, Couttas TA, Chen J, Chung LH, Liu D, Wadham C, Hogg PJ, Gao X, Vadas MA, Gamble JR, Don AS, Xia P, Qi Y. Aji G, et al. Among authors: qi y. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24434-24442. doi: 10.1073/pnas.2007856117. Epub 2020 Sep 11. Proc Natl Acad Sci U S A. 2020. PMID: 32917816 Free PMC article.
Role of Sphingosine Kinase in Type 2 Diabetes Mellitus.
Qi Y, Wang W, Song Z, Aji G, Liu XT, Xia P. Qi Y, et al. Front Endocrinol (Lausanne). 2021 Feb 9;11:627076. doi: 10.3389/fendo.2020.627076. eCollection 2020. Front Endocrinol (Lausanne). 2021. PMID: 33633691 Free PMC article. Review.
9,440 results