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A Non-Canonical Role for β-Secretase in the Retina.
Qian Q, Mitter SK, Pay SL, Qi X, Rickman CB, Grant MB, Boulton ME. Qian Q, et al. Among authors: qi x. Adv Exp Med Biol. 2016;854:333-9. doi: 10.1007/978-3-319-17121-0_44. Adv Exp Med Biol. 2016. PMID: 26427429 Review.
Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase).
Kielczewski JL, Li Calzi S, Shaw LC, Cai J, Qi X, Ruan Q, Wu L, Liu L, Hu P, Chan-Ling T, Mames RN, Firth S, Baxter RC, Turowski P, Busik JV, Boulton ME, Grant MB. Kielczewski JL, et al. Among authors: qi x. Invest Ophthalmol Vis Sci. 2011 Oct 21;52(11):8278-86. doi: 10.1167/iovs.11-8167. Invest Ophthalmol Vis Sci. 2011. PMID: 21931131 Free PMC article.
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, Joussen AM, Boulton ME. Cai J, et al. Among authors: qi x. EMBO Mol Med. 2012 Sep;4(9):980-91. doi: 10.1002/emmm.201101084. Epub 2012 Aug 20. EMBO Mol Med. 2012. PMID: 22903875 Free PMC article.
9,054 results