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Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial.
Chow CK, Atkins ER, Hillis GS, Nelson MR, Reid CM, Schlaich MP, Hay P, Rogers K, Billot L, Burke M, Chalmers J, Neal B, Patel A, Usherwood T, Webster R, Rodgers A; QUARTET Investigators. Chow CK, et al. Lancet. 2021 Sep 18;398(10305):1043-1052. doi: 10.1016/S0140-6736(21)01922-X. Epub 2021 Aug 29. Lancet. 2021. PMID: 34469767 Clinical Trial.
Therapeutic Inertia With Initial Low-Dose Quadruple Combination Therapy for Hypertension: Results From the QUARTET Trial.
Wang N, Von Huben A, Marschner S, Nelson MR, Nolde JM, Schlaich MP, Figtree G, Hillis GS, Usherwood T, Reid CM, Chalmers J, Jansen S, Atkins ER, Billot L, Chow C, Rodgers A; QUARTET Investigators. Wang N, et al. Hypertension. 2024 May;81(5):1087-1094. doi: 10.1161/HYPERTENSIONAHA.123.22284. Epub 2024 Mar 13. Hypertension. 2024. PMID: 38477128 Clinical Trial.