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Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.
Duan J, Matute JD, Unger LW, Hanley T, Schnell A, Lin X, Krupka N, Griebel P, Lambden C, Sit B, Grootjans J, Pyzik M, Sommer F, Kaiser S, Falk-Paulsen M, Grasberger H, Kao JY, Fuhrer T, Li H, Paik D, Lee Y, Refetoff S, Glickman JN, Paton AW, Bry L, Paton JC, Sauer U, Macpherson AJ, Rosenstiel P, Kuchroo VK, Waldor MK, Huh JR, Kaser A, Blumberg RS. Duan J, et al. Among authors: pyzik m. Immunity. 2023 May 9;56(5):1115-1131.e9. doi: 10.1016/j.immuni.2023.02.018. Epub 2023 Mar 13. Immunity. 2023. PMID: 36917985 Free PMC article.
Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Huang YH, et al. Among authors: pyzik m. Nature. 2024 Feb;626(8001):E19. doi: 10.1038/s41586-024-07164-y. Nature. 2024. PMID: 38336833 No abstract available.
The therapeutic age of the neonatal Fc receptor.
Pyzik M, Kozicky LK, Gandhi AK, Blumberg RS. Pyzik M, et al. Nat Rev Immunol. 2023 Jul;23(7):415-432. doi: 10.1038/s41577-022-00821-1. Epub 2023 Feb 1. Nat Rev Immunol. 2023. PMID: 36726033 Free PMC article. Review.
FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
Cines DB, Zaitsev S, Rauova L, Rux AH, Stepanova V, Krishnaswamy S, Sarkar A, Kowalska MA, Zhao G, Mast AE, Blumberg LJ, McCrae KR, Poncz M, Hubbard JJ, Pyzik M, Blumberg RS. Cines DB, et al. Among authors: pyzik m. Blood. 2020 Jun 4;135(23):2085-2093. doi: 10.1182/blood.2019001133. Blood. 2020. PMID: 32187355 Free PMC article.
Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.
Blumberg LJ, Humphries JE, Jones SD, Pearce LB, Holgate R, Hearn A, Cheung J, Mahmood A, Del Tito B, Graydon JS, Stolz LE, Bitonti A, Purohit S, de Graaf D, Kacena K, Andersen JT, Christianson GJ, Roopenian DC, Hubbard JJ, Gandhi AK, Lasseter K, Pyzik M, Blumberg RS. Blumberg LJ, et al. Among authors: pyzik m. Sci Adv. 2019 Dec 18;5(12):eaax9586. doi: 10.1126/sciadv.aax9586. eCollection 2019 Dec. Sci Adv. 2019. PMID: 31897428 Free PMC article. Clinical Trial.
The Neonatal Fc Receptor (FcRn): A Misnomer?
Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS. Pyzik M, et al. Front Immunol. 2019 Jul 10;10:1540. doi: 10.3389/fimmu.2019.01540. eCollection 2019. Front Immunol. 2019. PMID: 31354709 Free PMC article. Review.
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