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Emerging Therapeutic Agents for Colorectal Cancer.
Nalli M, Puxeddu M, La Regina G, Gianni S, Silvestri R. Nalli M, et al. Among authors: puxeddu m. Molecules. 2021 Dec 9;26(24):7463. doi: 10.3390/molecules26247463. Molecules. 2021. PMID: 34946546 Free PMC article. Review.
Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance.
Van Dycke J, Puxeddu M, La Regina G, Mastrangelo E, Tarantino D, Rymenants J, Sebastiani J, Nalli M, Matthijnssens J, Neyts J, Silvestri R, Rocha-Pereira J. Van Dycke J, et al. Among authors: puxeddu m. Pharmaceuticals (Basel). 2021 Sep 30;14(10):1006. doi: 10.3390/ph14101006. Pharmaceuticals (Basel). 2021. PMID: 34681230 Free PMC article.
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Sebastiani J, Puxeddu M, Nalli M, Bai R, Altieri L, Rovella P, Gaudio E, Trisciuoglio D, Spriano F, Lavia P, Fionda C, Masci D, Urbani A, Bigogno C, Dondio G, Hamel E, Bertoni F, Silvestri R, La Regina G. Sebastiani J, et al. Among authors: puxeddu m. Eur J Med Chem. 2023 Jan 15;246:114997. doi: 10.1016/j.ejmech.2022.114997. Epub 2022 Dec 5. Eur J Med Chem. 2023. PMID: 36502578
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent.
Nalli M, Di Magno L, Wen Y, Liu X, D'Ambrosio M, Puxeddu M, Parisi A, Sebastiani J, Sorato A, Coluccia A, Ripa S, Di Pastena F, Capelli D, Montanari R, Masci D, Urbani A, Naro C, Sette C, Orlando V, D'Angelo S, Biagioni S, Bigogno C, Dondio G, Pastore A, Stornaiuolo M, Canettieri G, Liu T, Silvestri R, La Regina G. Nalli M, et al. Among authors: puxeddu m. ACS Pharmacol Transl Sci. 2023 Jul 3;6(7):1087-1103. doi: 10.1021/acsptsci.3c00092. eCollection 2023 Jul 14. ACS Pharmacol Transl Sci. 2023. PMID: 37470018 Free article.
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells.
Masci D, Puxeddu M, Di Magno L, D'Ambrosio M, Parisi A, Nalli M, Bai R, Coluccia A, Sciò P, Orlando V, D'Angelo S, Biagioni S, Urbani A, Hamel E, Nocentini A, Filiberti S, Turati M, Ronca R, Kopecka J, Riganti C, Fionda C, Bordone R, Della Rocca G, Canettieri G, Supuran CT, Silvestri R, La Regina G. Masci D, et al. Among authors: puxeddu m. J Med Chem. 2023 Nov 9;66(21):14824-14842. doi: 10.1021/acs.jmedchem.3c01424. Epub 2023 Oct 30. J Med Chem. 2023. PMID: 37902628 Free PMC article.
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.
Puxeddu M, Shen H, Bai R, Coluccia A, Bufano M, Nalli M, Sebastiani J, Brancaccio D, Da Pozzo E, Tremolanti C, Martini C, Orlando V, Biagioni S, Sinicropi MS, Ceramella J, Iacopetta D, Coluccia AML, Hamel E, Liu T, Silvestri R, La Regina G. Puxeddu M, et al. Eur J Med Chem. 2021 Oct 5;221:113532. doi: 10.1016/j.ejmech.2021.113532. Epub 2021 May 5. Eur J Med Chem. 2021. PMID: 34052717
Anticancer Activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor.
Coluccia A, Bufano M, La Regina G, Puxeddu M, Toto A, Paone A, Bouzidi A, Musto G, Badolati N, Orlando V, Biagioni S, Masci D, Cantatore C, Cirilli R, Cutruzzolà F, Gianni S, Stornaiuolo M, Silvestri R. Coluccia A, et al. Among authors: puxeddu m. Cancers (Basel). 2022 Mar 7;14(5):1358. doi: 10.3390/cancers14051358. Cancers (Basel). 2022. PMID: 35267666 Free PMC article.
31 results