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Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong GS, Zhou J, Liu JB, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O'Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R, Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ. Wong GS, et al. Among authors: puschhof j. Nat Med. 2018 Jul;24(7):968-977. doi: 10.1038/s41591-018-0022-x. Epub 2018 May 28. Nat Med. 2018. PMID: 29808010 Free PMC article.
Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong GS, Zhou J, Bin Liu J, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O'Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R, Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ. Wong GS, et al. Among authors: puschhof j. Nat Med. 2018 Oct;24(10):1627. doi: 10.1038/s41591-018-0168-6. Nat Med. 2018. PMID: 30093730
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, Miao Y, van der Linden R, van der Elst S; Genomics England Research Consortium; Garcia KC, Top J, Willems RJL, Giannakis M, Bonnet R, Quirke P, Meyerson M, Cuppen E, van Boxtel R, Clevers H. Pleguezuelos-Manzano C, et al. Among authors: puschhof j. Nature. 2020 Apr;580(7802):269-273. doi: 10.1038/s41586-020-2080-8. Epub 2020 Feb 27. Nature. 2020. PMID: 32106218 Free PMC article.
A bacterial mutational footprint in colorectal cancer genomes.
Rosendahl Huber A, Pleguezuelos-Manzano C, Puschhof J. Rosendahl Huber A, et al. Among authors: puschhof j. Br J Cancer. 2021 May;124(11):1751-1753. doi: 10.1038/s41416-021-01273-5. Epub 2021 Mar 19. Br J Cancer. 2021. PMID: 33742142 Free PMC article.
Intestinal organoid cocultures with microbes.
Puschhof J, Pleguezuelos-Manzano C, Martinez-Silgado A, Akkerman N, Saftien A, Boot C, de Waal A, Beumer J, Dutta D, Heo I, Clevers H. Puschhof J, et al. Nat Protoc. 2021 Oct;16(10):4633-4649. doi: 10.1038/s41596-021-00589-z. Epub 2021 Aug 11. Nat Protoc. 2021. PMID: 34381208 Review.
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses.
Beumer J, Geurts MH, Lamers MM, Puschhof J, Zhang J, van der Vaart J, Mykytyn AZ, Breugem TI, Riesebosch S, Schipper D, van den Doel PB, de Lau W, Pleguezuelos-Manzano C, Busslinger G, Haagmans BL, Clevers H. Beumer J, et al. Among authors: puschhof j. Nat Commun. 2021 Sep 17;12(1):5498. doi: 10.1038/s41467-021-25729-7. Nat Commun. 2021. PMID: 34535662 Free PMC article.
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene.
Allen J, Rosendahl Huber A, Pleguezuelos-Manzano C, Puschhof J, Wu S, Wu X, Boot C, Saftien A, O'Hagan HM, Wang H, van Boxtel R, Clevers H, Sears CL. Allen J, et al. Among authors: puschhof j. Microbiol Spectr. 2022 Jun 29;10(3):e0105522. doi: 10.1128/spectrum.01055-22. Epub 2022 May 19. Microbiol Spectr. 2022. PMID: 35587635 Free PMC article.
The Myofibroblasts' War on Drugs.
Puschhof J, Clevers H. Puschhof J, et al. Dev Cell. 2018 Sep 24;46(6):669-670. doi: 10.1016/j.devcel.2018.09.008. Dev Cell. 2018. PMID: 30253163 Free article.
35 results