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Retinoids in clinical use.
Njar VC, Gediya L, Purushottamachar P, Chopra P, Belosay A, Patel JB. Njar VC, et al. Among authors: purushottamachar p. Med Chem. 2006 Jul;2(4):431-8. doi: 10.2174/157340606777724022. Med Chem. 2006. PMID: 16848757 Review.
Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.
Gediya LK, Belosay A, Khandelwal A, Purushottamachar P, Njar VC. Gediya LK, et al. Among authors: purushottamachar p. Bioorg Med Chem. 2008 Mar 15;16(6):3352-60. doi: 10.1016/j.bmc.2007.12.007. Epub 2007 Dec 8. Bioorg Med Chem. 2008. PMID: 18166465 Free PMC article.
Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.
Gediya LK, Khandelwal A, Patel J, Belosay A, Sabnis G, Mehta J, Purushottamachar P, Njar VC. Gediya LK, et al. Among authors: purushottamachar p. J Med Chem. 2008 Jul 10;51(13):3895-904. doi: 10.1021/jm8001839. Epub 2008 Jun 11. J Med Chem. 2008. PMID: 18543902
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.
Bruno RD, Vasaitis TS, Gediya LK, Purushottamachar P, Godbole AM, Ates-Alagoz Z, Brodie AM, Njar VC. Bruno RD, et al. Among authors: purushottamachar p. Steroids. 2011 Nov;76(12):1268-79. doi: 10.1016/j.steroids.2011.06.002. Epub 2011 Jun 24. Steroids. 2011. PMID: 21729712 Free PMC article.
Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus.
Goss PE, Qi S, Hu H, Gediya LK, Purushottamachar P, Godbole AM, Njar VC. Goss PE, et al. Among authors: purushottamachar p. Breast Cancer Res Treat. 2012 May;133(1):137-44. doi: 10.1007/s10549-011-1724-7. Epub 2011 Aug 14. Breast Cancer Res Treat. 2012. PMID: 21842418 Free PMC article.
34 results