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Defining neutralization and allostery by antibodies against COVID-19 variants.
Tulsian NK, Palur RV, Qian X, Gu Y, D/O Shunmuganathan B, Samsudin F, Wong YH, Lin J, Purushotorman K, Kozma MM, Wang B, Lescar J, Wang CI, Gupta RK, Bond PJ, MacAry PA. Tulsian NK, et al. Among authors: purushotorman k. Nat Commun. 2023 Nov 1;14(1):6967. doi: 10.1038/s41467-023-42408-x. Nat Commun. 2023. PMID: 37907459 Free PMC article.
Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.
Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA. Gu Y, et al. Among authors: purushotorman k. Nat Commun. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1. Nat Commun. 2019. PMID: 30792391 Free PMC article.
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets.
Raghuvamsi PV, Tulsian NK, Samsudin F, Qian X, Purushotorman K, Yue G, Kozma MM, Hwa WY, Lescar J, Bond PJ, MacAry PA, Anand GS. Raghuvamsi PV, et al. Among authors: purushotorman k. Elife. 2021 Feb 8;10:e63646. doi: 10.7554/eLife.63646. Elife. 2021. PMID: 33554856 Free PMC article.
A rapid simple point-of-care assay for the detection of SARS-CoV-2 neutralizing antibodies.
Kongsuphol P, Jia H, Cheng HL, Gu Y, Shunmuganathan BD, Chen MW, Lim SM, Ng SY, Tambyah PA, Nasir H, Gao X, Tay D, Kim S, Gupta R, Qian X, Kozma MM, Purushotorman K, McBee ME, MacAry PA, Sikes HD, Preiser PR. Kongsuphol P, et al. Among authors: purushotorman k. Commun Med (Lond). 2021 Nov 11;1:46. doi: 10.1038/s43856-021-00045-9. eCollection 2021. Commun Med (Lond). 2021. PMID: 35602218 Free PMC article.
Analyzing COVID-19 Vaccine Responses in Transplant Recipients.
Murali TM, Shunmuganathan B, Trueman EL, Gupta R, Tan RSW, Sran HK, D'Costa MR, Wong ET, Gu Y, Cui J, Wee Kun K, Lim AQH, Qian X, Purushotorman K, Chen J, MacAry PA, Vathsala A. Murali TM, et al. Among authors: purushotorman k. Immunohorizons. 2023 Oct 1;7(10):708-717. doi: 10.4049/immunohorizons.2300071. Immunohorizons. 2023. PMID: 37889158 Free PMC article.
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody.
Chan CEZ, Seah SGK, Chye H, Massey S, Torres M, Lim APC, Wong SKK, Neo JJY, Wong PS, Lim JH, Loh GSL, Wang D, Boyd-Kirkup JD, Guan S, Thakkar D, Teo GH, Purushotorman K, Hutchinson PE, Young BE, Low JG, MacAry PA, Hentze H, Prativadibhayankara VS, Ethirajulu K, Comer JE, Tseng CK, Barrett ADT, Ingram PJ, Brasel T, Hanson BJ. Chan CEZ, et al. Among authors: purushotorman k. PLoS One. 2021 Jun 23;16(6):e0253487. doi: 10.1371/journal.pone.0253487. eCollection 2021. PLoS One. 2021. PMID: 34161386 Free PMC article.
An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis.
Krishnananthasivam S, Li H, Bouzeyen R, Shunmuganathan B, Purushotorman K, Liao X, Du F, Friis CGK, Crawshay-Williams F, Boon LH, Xinlei Q, Chan CEZ, Sobota R, Kozma M, Barcelli V, Wang G, Huang H, Floto A, Bifani P, Javid B, MacAry PA. Krishnananthasivam S, et al. Among authors: purushotorman k. NPJ Vaccines. 2023 Aug 25;8(1):127. doi: 10.1038/s41541-023-00710-1. NPJ Vaccines. 2023. PMID: 37626082 Free PMC article.
Author Correction: An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis.
Krishnananthasivam S, Li H, Bouzeyen R, Shunmuganathan B, Purushotorman K, Liao X, Du F, Friis CGK, Crawshay-Williams F, Boon LH, Xinlei Q, Chan CEZ, Sobota R, Kozma M, Barcelli V, Wang G, Huang H, Floto A, Bifani P, Javid B, MacAry PA. Krishnananthasivam S, et al. Among authors: purushotorman k. NPJ Vaccines. 2023 Sep 25;8(1):136. doi: 10.1038/s41541-023-00735-6. NPJ Vaccines. 2023. PMID: 37749097 Free PMC article. No abstract available.
13 results