Purkiss AG - Search Results

1

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.

Rzechorzek NJ, Kunzelmann S, Purkiss AG, Silva Dos Santos M, MacRae JI, Taylor IA, Fugger K, West SC. Rzechorzek NJ, et al. Among authors: purkiss ag. Nat Commun. 2023 Oct 26;14(1):6809. doi: 10.1038/s41467-023-42544-4. Nat Commun. 2023. PMID: 37884503 Free PMC article.

2

Structure of the cohesin loader Scc2.

Chao WC, Murayama Y, Muñoz S, Jones AW, Wade BO, Purkiss AG, Hu XW, Borg A, Snijders AP, Uhlmann F, Singleton MR. Chao WC, et al. Among authors: purkiss ag. Nat Commun. 2017 Jan 6;8:13952. doi: 10.1038/ncomms13952. Nat Commun. 2017. PMID: 28059076 Free PMC article.

3

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome.

Goswami P, Abid Ali F, Douglas ME, Locke J, Purkiss A, Janska A, Eickhoff P, Early A, Nans A, Cheung AMC, Diffley JFX, Costa A. Goswami P, et al. Nat Commun. 2018 Nov 29;9(1):5061. doi: 10.1038/s41467-018-07417-1. Nat Commun. 2018. PMID: 30498216 Free PMC article.

4

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.

Dagil R, Ball NJ, Ogrodowicz RW, Hobor F, Purkiss AG, Kelly G, Martin SR, Taylor IA, Ramos A. Dagil R, et al. Among authors: purkiss ag. Nucleic Acids Res. 2019 May 7;47(8):4334-4348. doi: 10.1093/nar/gkz136. Nucleic Acids Res. 2019. PMID: 30864660 Free PMC article.

5

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Morris ER, Caswell SJ, Kunzelmann S, Arnold LH, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: purkiss ag. Nat Commun. 2020 Jun 23;11(1):3165. doi: 10.1038/s41467-020-16983-2. Nat Commun. 2020. PMID: 32576829 Free PMC article.

6

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R_p- and S_p-dNTPαS Diastereomers.

Morris ER, Kunzelmann S, Caswell SJ, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: purkiss ag. Biochemistry. 2021 Jun 1;60(21):1682-1698. doi: 10.1021/acs.biochem.0c00944. Epub 2021 May 14. Biochemistry. 2021. PMID: 33988981 Free PMC article.

7

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly.

Houghton FM, Adams SE, Ríos AS, Masino L, Purkiss AG, Briggs DC, Ledda F, McDonald NQ. Houghton FM, et al. Among authors: purkiss ag. Nat Commun. 2023 Nov 20;14(1):7551. doi: 10.1038/s41467-023-43148-8. Nat Commun. 2023. PMID: 37985758 Free PMC article.

8

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.

de Chiara C, Homšak M, Prosser GA, Douglas HL, Garza-Garcia A, Kelly G, Purkiss AG, Tate EW, de Carvalho LPS. de Chiara C, et al. Among authors: purkiss ag. Nat Chem Biol. 2020 Jun;16(6):686-694. doi: 10.1038/s41589-020-0498-9. Epub 2020 Mar 16. Nat Chem Biol. 2020. PMID: 32203411 Free PMC article.

9

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing.

Adams SE, Purkiss AG, Knowles PP, Nans A, Briggs DC, Borg A, Earl CP, Goodman KM, Nawrotek A, Borg AJ, McIntosh PB, Houghton FM, Kjær S, McDonald NQ. Adams SE, et al. Among authors: purkiss ag. Structure. 2021 Jul 1;29(7):694-708.e7. doi: 10.1016/j.str.2020.12.012. Epub 2021 Jan 22. Structure. 2021. PMID: 33484636 Free PMC article.

10

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.

Spratt DE, Martinez-Torres RJ, Noh YJ, Mercier P, Manczyk N, Barber KR, Aguirre JD, Burchell L, Purkiss A, Walden H, Shaw GS. Spratt DE, et al. Nat Commun. 2013;4:1983. doi: 10.1038/ncomms2983. Nat Commun. 2013. PMID: 23770917 Free PMC article.

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