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A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma.
Gamble LD, Purgato S, Henderson MJ, Di Giacomo S, Russell AJ, Pigini P, Murray J, Valli E, Milazzo G, Giorgi FM, Cowley M, Ashton LJ, Bhalshankar J, Schleiermacher G, Rihani A, Van Maerken T, Vandesompele J, Speleman F, Versteeg R, Koster J, Eggert A, Noguera R, Stallings RL, Tonini GP, Fong K, Vaksman Z, Diskin SJ, Maris JM, London WB, Marshall GM, Ziegler DS, Hogarty MD, Perini G, Norris MD, Haber M. Gamble LD, et al. Among authors: purgato s. Cancers (Basel). 2021 Apr 9;13(8):1807. doi: 10.3390/cancers13081807. Cancers (Basel). 2021. PMID: 33918978 Free PMC article.
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.
Gamble LD, Purgato S, Murray J, Xiao L, Yu DMT, Hanssen KM, Giorgi FM, Carter DR, Gifford AJ, Valli E, Milazzo G, Kamili A, Mayoh C, Liu B, Eden G, Sarraf S, Allan S, Di Giacomo S, Flemming CL, Russell AJ, Cheung BB, Oberthuer A, London WB, Fischer M, Trahair TN, Fletcher JI, Marshall GM, Ziegler DS, Hogarty MD, Burns MR, Perini G, Norris MD, Haber M. Gamble LD, et al. Among authors: purgato s. Sci Transl Med. 2019 Jan 30;11(477):eaau1099. doi: 10.1126/scitranslmed.aau1099. Sci Transl Med. 2019. PMID: 30700572
MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.
O'Brien R, Tran SL, Maritz MF, Liu B, Kong CF, Purgato S, Yang C, Murray J, Russell AJ, Flemming CL, von Jonquieres G, Pickett HA, London WB, Haber M, Gunaratne PH, Norris MD, Perini G, Fletcher JI, MacKenzie KL. O'Brien R, et al. Among authors: purgato s. Cancer Res. 2016 Jun 15;76(12):3604-17. doi: 10.1158/0008-5472.CAN-15-0879. Epub 2016 Apr 13. Cancer Res. 2016. PMID: 27197171
MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.
Ferrucci F, Ciaccio R, Monticelli S, Pigini P, di Giacomo S, Purgato S, Erriquez D, Bernardoni R, Norris M, Haber M, Milazzo G, Perini G. Ferrucci F, et al. Among authors: purgato s. Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):235-245. doi: 10.1016/j.bbagrm.2018.01.007. Epub 2018 Feb 3. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 29408445
Corrigendum to: "MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma" [Biochim. Biophys. Acta, Gene Regul. Mech. 1861 (2018) 235-245].
Ferrucci F, Ciaccio R, Monticelli S, Pigini P, Di Giacomo S, Purgato S, Erriquez D, Bernardoni R, Norris MD, Haber M, Milazzo G, Perini G. Ferrucci F, et al. Among authors: purgato s. Biochim Biophys Acta Gene Regul Mech. 2020 Nov;1863(11):194645. doi: 10.1016/j.bbagrm.2020.194645. Epub 2020 Oct 30. Biochim Biophys Acta Gene Regul Mech. 2020. PMID: 33139218 No abstract available.
Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas.
Macchia G, Nord KH, Zoli M, Purgato S, D'Addabbo P, Whelan CW, Carbone L, Perini G, Mertens F, Rocchi M, Storlazzi CT. Macchia G, et al. Among authors: purgato s. Genes Chromosomes Cancer. 2015 Mar;54(3):156-67. doi: 10.1002/gcc.22228. Epub 2014 Nov 25. Genes Chromosomes Cancer. 2015. PMID: 25421174
Centromere sliding on a mammalian chromosome.
Purgato S, Belloni E, Piras FM, Zoli M, Badiale C, Cerutti F, Mazzagatti A, Perini G, Della Valle G, Nergadze SG, Sullivan KF, Raimondi E, Rocchi M, Giulotto E. Purgato S, et al. Chromosoma. 2015 Jun;124(2):277-87. doi: 10.1007/s00412-014-0493-6. Epub 2014 Nov 21. Chromosoma. 2015. PMID: 25413176 Free PMC article.
Epigenetic origin of evolutionary novel centromeres.
Tolomeo D, Capozzi O, Stanyon RR, Archidiacono N, D'Addabbo P, Catacchio CR, Purgato S, Perini G, Schempp W, Huddleston J, Malig M, Eichler EE, Rocchi M. Tolomeo D, et al. Among authors: purgato s. Sci Rep. 2017 Feb 3;7:41980. doi: 10.1038/srep41980. Sci Rep. 2017. PMID: 28155877 Free PMC article.
The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer.
Macchia G, Severgnini M, Purgato S, Tolomeo D, Casciaro H, Cifola I, L'Abbate A, Loverro A, Palumbo O, Carella M, Bianchini L, Perini G, De Bellis G, Mertens F, Rocchi M, Storlazzi CT. Macchia G, et al. Among authors: purgato s. Genetics. 2018 Mar;208(3):951-961. doi: 10.1534/genetics.117.300552. Epub 2017 Dec 26. Genetics. 2018. PMID: 29279323 Free PMC article.
24 results