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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
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2008 3
2011 3
2012 5
2013 1
2014 2
2015 2
2016 3
2017 2
2019 2
2021 1
2022 5
2023 4
2024 0

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Page 1
VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
Thankan RS, Thomas E, Purushottamachar P, Weber DJ, Ramamurthy VP, Huang W, Kane MA, Njar VCO. Thankan RS, et al. Among authors: purushottamachar p. Front Oncol. 2023 Sep 11;13:1240996. doi: 10.3389/fonc.2023.1240996. eCollection 2023. Front Oncol. 2023. PMID: 37766871 Free PMC article.
Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3β Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model.
Thankan RS, Thomas E, Purushottamachar P, Weber DJ, Njar VCO. Thankan RS, et al. Among authors: purushottamachar p. Bioorg Chem. 2023 Oct;139:106700. doi: 10.1016/j.bioorg.2023.106700. Epub 2023 Jun 25. Bioorg Chem. 2023. PMID: 37392559
Transcriptome profiling reveals that VNPP433-3β, the lead next-generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial-mesenchymal transition and stem cell markers.
Thomas E, Thankan RS, Purushottamachar P, Huang W, Kane MA, Zhang Y, Ambulos N, Weber DJ, Njar VCO. Thomas E, et al. Among authors: purushottamachar p. Mol Carcinog. 2022 Jul;61(7):643-654. doi: 10.1002/mc.23406. Epub 2022 May 5. Mol Carcinog. 2022. PMID: 35512605 Free PMC article.
Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo.
Kwegyir-Afful AK, Ramalingam S, Ramamurthy VP, Purushottamachar P, Murigi FN, Vasaitis TS, Huang W, Kane MA, Zhang Y, Ambulos N, Tiwari S, Srivastava P, Nnane IP, Hussain A, Qiu Y, Weber DJ, Njar VCO. Kwegyir-Afful AK, et al. Among authors: purushottamachar p. Cancers (Basel). 2019 Oct 24;11(11):1637. doi: 10.3390/cancers11111637. Cancers (Basel). 2019. PMID: 31653008 Free PMC article.
34 results