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Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems.
Alon S, Goodwin DR, Sinha A, Wassie AT, Chen F, Daugharthy ER, Bando Y, Kajita A, Xue AG, Marrett K, Prior R, Cui Y, Payne AC, Yao CC, Suk HJ, Wang R, Yu CJ, Tillberg P, Reginato P, Pak N, Liu S, Punthambaker S, Iyer EPR, Kohman RE, Miller JA, Lein ES, Lako A, Cullen N, Rodig S, Helvie K, Abravanel DL, Wagle N, Johnson BE, Klughammer J, Slyper M, Waldman J, Jané-Valbuena J, Rozenblatt-Rosen O, Regev A; IMAXT Consortium; Church GM, Marblestone AH, Boyden ES. Alon S, et al. Among authors: punthambaker s. Science. 2021 Jan 29;371(6528):eaax2656. doi: 10.1126/science.aax2656. Science. 2021. PMID: 33509999 Free PMC article.
Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses.
Liu S, Punthambaker S, Iyer EPR, Ferrante T, Goodwin D, Fürth D, Pawlowski AC, Jindal K, Tam JM, Mifflin L, Alon S, Sinha A, Wassie AT, Chen F, Cheng A, Willocq V, Meyer K, Ling KH, Camplisson CK, Kohman RE, Aach J, Lee JH, Yankner BA, Boyden ES, Church GM. Liu S, et al. Among authors: punthambaker s. Nucleic Acids Res. 2021 Jun 4;49(10):e58. doi: 10.1093/nar/gkab120. Nucleic Acids Res. 2021. PMID: 33693773 Free PMC article.
A single combination gene therapy treats multiple age-related diseases.
Davidsohn N, Pezone M, Vernet A, Graveline A, Oliver D, Slomovic S, Punthambaker S, Sun X, Liao R, Bonventre JV, Church GM. Davidsohn N, et al. Among authors: punthambaker s. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23505-23511. doi: 10.1073/pnas.1910073116. Epub 2019 Nov 4. Proc Natl Acad Sci U S A. 2019. PMID: 31685628 Free PMC article.
Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism.
Scheiman J, Luber JM, Chavkin TA, MacDonald T, Tung A, Pham LD, Wibowo MC, Wurth RC, Punthambaker S, Tierney BT, Yang Z, Hattab MW, Avila-Pacheco J, Clish CB, Lessard S, Church GM, Kostic AD. Scheiman J, et al. Among authors: punthambaker s. Nat Med. 2019 Jul;25(7):1104-1109. doi: 10.1038/s41591-019-0485-4. Epub 2019 Jun 24. Nat Med. 2019. PMID: 31235964 Free PMC article.
Multiplex Single-Molecule Kinetics of Nanopore-Coupled Polymerases.
Palla M, Punthambaker S, Stranges B, Vigneault F, Nivala J, Wiegand D, Ayer A, Craig T, Gremyachinskiy D, Franklin H, Sun S, Pollard J, Trans A, Arnold C, Schwab C, Mcgaw C, Sarvabhowman P, Dalal D, Thai E, Amato E, Lederman I, Taing M, Kelley S, Qwan A, Fuller CW, Roever S, Church GM. Palla M, et al. Among authors: punthambaker s. ACS Nano. 2021 Jan 26;15(1):489-502. doi: 10.1021/acsnano.0c05226. Epub 2020 Dec 28. ACS Nano. 2021. PMID: 33370106