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A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes.
Paini A, Punt A, Viton F, Scholz G, Delatour T, Marin-Kuan M, Schilter B, van Bladeren PJ, Rietjens IM. Paini A, et al. Among authors: punt a. Toxicol Appl Pharmacol. 2010 May 15;245(1):57-66. doi: 10.1016/j.taap.2010.01.016. Epub 2010 Feb 6. Toxicol Appl Pharmacol. 2010. PMID: 20144636
Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect.
Alhusainy W, Paini A, Punt A, Louisse J, Spenkelink A, Vervoort J, Delatour T, Scholz G, Schilter B, Adams T, van Bladeren PJ, Rietjens IM. Alhusainy W, et al. Among authors: punt a. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):179-90. doi: 10.1016/j.taap.2010.02.017. Epub 2010 Mar 11. Toxicol Appl Pharmacol. 2010. PMID: 20226806
124 results