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Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
Eduful BJ, O'Byrne SN, Temme L, Asquith CRM, Liang Y, Picado A, Pilotte JR, Hossain MA, Wells CI, Zuercher WJ, Catta-Preta CMC, Zonzini Ramos P, Santiago AS, Couñago RM, Langendorf CG, Nay K, Oakhill JS, Pulliam TL, Lin C, Awad D, Willson TM, Frigo DE, Scott JW, Drewry DH. Eduful BJ, et al. Among authors: pulliam tl. J Med Chem. 2021 Aug 12;64(15):10849-10877. doi: 10.1021/acs.jmedchem.0c02274. Epub 2021 Jul 15. J Med Chem. 2021. PMID: 34264658 Free PMC article.
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.
White MA, Tsouko E, Lin C, Rajapakshe K, Spencer JM, Wilkenfeld SR, Vakili SS, Pulliam TL, Awad D, Nikolos F, Katreddy RR, Kaipparettu BA, Sreekumar A, Zhang X, Cheung E, Coarfa C, Frigo DE. White MA, et al. Among authors: pulliam tl. Endocr Relat Cancer. 2018 Apr;25(4):453-469. doi: 10.1530/ERC-17-0051. Epub 2018 Feb 5. Endocr Relat Cancer. 2018. PMID: 29431615 Free PMC article.
Prostate Cancer Energetics and Biosynthesis.
Lin C, Salzillo TC, Bader DA, Wilkenfeld SR, Awad D, Pulliam TL, Dutta P, Pudakalakatti S, Titus M, McGuire SE, Bhattacharya PK, Frigo DE. Lin C, et al. Among authors: pulliam tl. Adv Exp Med Biol. 2019;1210:185-237. doi: 10.1007/978-3-030-32656-2_10. Adv Exp Med Biol. 2019. PMID: 31900911 Free PMC article. Review.
Regulation and role of CAMKK2 in prostate cancer.
Pulliam TL, Goli P, Awad D, Lin C, Wilkenfeld SR, Frigo DE. Pulliam TL, et al. Nat Rev Urol. 2022 Jun;19(6):367-380. doi: 10.1038/s41585-022-00588-z. Epub 2022 Apr 26. Nat Rev Urol. 2022. PMID: 35474107 Review.
SGC-CAMKK2-1: A Chemical Probe for CAMKK2.
Wells C, Liang Y, Pulliam TL, Lin C, Awad D, Eduful B, O'Byrne S, Hossain MA, Catta-Preta CMC, Ramos PZ, Gileadi O, Gileadi C, Couñago RM, Stork B, Langendorf CG, Nay K, Oakhill JS, Mukherjee D, Racioppi L, Means AR, York B, McDonnell DP, Scott JW, Frigo DE, Drewry DH. Wells C, et al. Among authors: pulliam tl. Cells. 2023 Jan 11;12(2):287. doi: 10.3390/cells12020287. Cells. 2023. PMID: 36672221 Free PMC article.
Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity.
Awad D, Cao PHA, Pulliam TL, Spradlin M, Subramani E, Tellman TV, Ribeiro CF, Muzzioli R, Jewell BE, Pakula H, Ackroyd JJ, Murray MM, Han JJ, Leng M, Jain A, Piyarathna B, Liu J, Song X, Zhang J, Klekers AR, Drake JM, Ittmann MM, Coarfa C, Piwnica-Worms D, Farach-Carson MC, Loda M, Eberlin LS, Frigo DE. Awad D, et al. Among authors: pulliam tl. Cancer Res. 2024 Mar 4;84(5):703-724. doi: 10.1158/0008-5472.CAN-23-0555. Cancer Res. 2024. PMID: 38038968