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127 results

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Page 1
The Spontaneous Incidence of Neurological Clinical Signs in Preclinical Species Using Cage-side Observations or High-definition Video Monitoring: A Retrospective Analysis.
Orciani C, Ballesteros C, Troncy E, Berthome C, Bujold K, Bennamoune N, Sparapani S, Pugsley MK, Paquette D, Boulay E, Authier S. Orciani C, et al. Among authors: pugsley mk. Int J Toxicol. 2024 Mar-Apr;43(2):123-133. doi: 10.1177/10915818231218984. Epub 2023 Dec 8. Int J Toxicol. 2024. PMID: 38063479
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis.
Boulay E, Miraucourt LS, Pugsley MK, Abernathy MM, Chui R, Dalton J, Demers M, Dybdal N, Gazaille E, Greiter-Wilke A, Hoffmann P, Huang H, LaDuke C, Norton K, Pierson JB, Reeves I, Roche B, Rossman EI, Schultze AE, Tang HM, Wisialowski T, Authier S. Boulay E, et al. Among authors: pugsley mk. J Pharmacol Toxicol Methods. 2023 May-Jun;121:107266. doi: 10.1016/j.vascn.2023.107266. Epub 2023 Mar 22. J Pharmacol Toxicol Methods. 2023. PMID: 36963703 Free article.
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
Rossman EI, Wisialowski TA, Vargas HM, Valentin JP, Rolf MG, Roche BM, Riley S, Pugsley MK, Nichols J, Li D, Leishman DJ, Kleiman RB, Greiter-Wilke A, Gintant GA, Engwall MJ, Delaunois A, Authier S. Rossman EI, et al. Among authors: pugsley mk. J Pharmacol Toxicol Methods. 2023 Sep-Oct;123:107270. doi: 10.1016/j.vascn.2023.107270. Epub 2023 May 8. J Pharmacol Toxicol Methods. 2023. PMID: 37164235
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute.
Vargas HM, Rossman EI, Wisialowski TA, Nichols J, Pugsley MK, Roche B, Gintant GA, Greiter-Wilke A, Kleiman RB, Valentin JP, Leishman DJ. Vargas HM, et al. Among authors: pugsley mk. J Pharmacol Toxicol Methods. 2023 May-Jun;121:107265. doi: 10.1016/j.vascn.2023.107265. Epub 2023 Mar 28. J Pharmacol Toxicol Methods. 2023. PMID: 36997076 Free article. Review.
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) cardiac safety committee.
Pierson JB, Berridge B, Blinova K, Brooks MB, Eldridge S, O'Brien CE, Pugsley MK, Schultze AE, Smith G, Stockbridge N, Valentin JP, Vicente J. Pierson JB, et al. Among authors: pugsley mk. J Pharmacol Toxicol Methods. 2024 May 4:107511. doi: 10.1016/j.vascn.2024.107511. Online ahead of print. J Pharmacol Toxicol Methods. 2024. PMID: 38710237 Free article.
The Challenges of Predicting Drug-Induced QTc Prolongation in Humans.
Valentin JP, Hoffmann P, Ortemann-Renon C, Koerner J, Pierson J, Gintant G, Willard J, Garnett C, Skinner M, Vargas HM, Wisialowski T, Pugsley MK. Valentin JP, et al. Among authors: pugsley mk. Toxicol Sci. 2022 Apr 26;187(1):3-24. doi: 10.1093/toxsci/kfac013. Toxicol Sci. 2022. PMID: 35148401 Free PMC article. Review.
127 results