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Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors.
Gorecki L, Andrys R, Schmidt M, Kucera T, Psotka M, Svobodova B, Hrabcova V, Hepnarova V, Bzonek P, Jun D, Kuca K, Korabecny J, Musilek K. Gorecki L, et al. Among authors: psotka m. ACS Med Chem Lett. 2019 Nov 26;11(1):65-71. doi: 10.1021/acsmedchemlett.9b00477. eCollection 2020 Jan 9. ACS Med Chem Lett. 2019. PMID: 31938465 Free PMC article.
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K. Soukup O, et al. Among authors: psotka m. Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657. Med Chem. 2018. PMID: 29332594
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators.
Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L, Mezeiova E, Psotka M, Jun D, Kuca K, Musilek K. Malinak D, et al. Among authors: psotka m. J Enzyme Inhib Med Chem. 2020 Dec;35(1):478-488. doi: 10.1080/14756366.2019.1710501. J Enzyme Inhib Med Chem. 2020. PMID: 31910701 Free PMC article.
Substituted Piperazines as Novel Potential Radioprotective Agents.
Filipova A, Marek J, Havelek R, Pejchal J, Jelicova M, Cizkova J, Majorosova M, Muckova L, Kucera T, Prchal L, Psotka M, Zivna N, Koutova D, Sinkorova Z, Rezacova M, Tichy A. Filipova A, et al. Among authors: psotka m. Molecules. 2020 Jan 25;25(3):532. doi: 10.3390/molecules25030532. Molecules. 2020. PMID: 31991816 Free PMC article.
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition.
Oleksak P, Psotka M, Vancurova M, Sapega O, Bieblova J, Reinis M, Rysanek D, Mikyskova R, Chalupova K, Malinak D, Svobodova J, Andrys R, Rehulkova H, Skopek V, Ngoc Lam P, Bartek J, Hodny Z, Musilek K. Oleksak P, et al. Among authors: psotka m. J Enzyme Inhib Med Chem. 2021 Dec;36(1):410-424. doi: 10.1080/14756366.2020.1871336. J Enzyme Inhib Med Chem. 2021. PMID: 33440995 Free PMC article.
Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides.
Kohoutova Z, Malinak D, Andrys R, Svobodova J, Psotka M, Schmidt M, Prchal L, Musilek K. Kohoutova Z, et al. Among authors: psotka m. J Enzyme Inhib Med Chem. 2022 Dec;37(1):760-767. doi: 10.1080/14756366.2022.2041628. J Enzyme Inhib Med Chem. 2022. PMID: 35193448 Free PMC article.
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