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The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors.
Biol Direct. 2023 Aug 1;18(1):43. doi: 10.1186/s13062-023-00375-9.
Biol Direct. 2023.
PMID: 37528429
Free PMC article.
Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer.
Pryde KR, Hirst J.
Pryde KR, et al.
J Biol Chem. 2011 May 20;286(20):18056-65. doi: 10.1074/jbc.M110.186841. Epub 2011 Mar 10.
J Biol Chem. 2011.
PMID: 21393237
Free PMC article.
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Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I.
Stephenson ZA, Harvey RF, Pryde KR, Mistry S, Hardy RE, Serreli R, Chung I, Allen TE, Stoneley M, MacFarlane M, Fischer PM, Hirst J, Kellam B, Willis AE.
Stephenson ZA, et al. Among authors: pryde kr.
Elife. 2020 May 20;9:e55845. doi: 10.7554/eLife.55845.
Elife. 2020.
PMID: 32432547
Free PMC article.
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The production of reactive oxygen species by complex I.
Hirst J, King MS, Pryde KR.
Hirst J, et al. Among authors: pryde kr.
Biochem Soc Trans. 2008 Oct;36(Pt 5):976-80. doi: 10.1042/BST0360976.
Biochem Soc Trans. 2008.
PMID: 18793173
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A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Pryde KR, Taanman JW, Schapira AH.
Pryde KR, et al.
Cell Rep. 2016 Dec 6;17(10):2522-2531. doi: 10.1016/j.celrep.2016.11.027.
Cell Rep. 2016.
PMID: 27926857
Free PMC article.
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Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature.
Trapotsi MA, Mouchet E, Williams G, Monteverde T, Juhani K, Turkki R, Miljković F, Martinsson A, Mervin L, Pryde KR, Müllers E, Barrett I, Engkvist O, Bender A, Moreau K.
Trapotsi MA, et al. Among authors: pryde kr.
ACS Chem Biol. 2022 Jul 15;17(7):1733-1744. doi: 10.1021/acschembio.2c00076. Epub 2022 Jul 6.
ACS Chem Biol. 2022.
PMID: 35793809
Free PMC article.
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PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy.
Pryde KR, Smith HL, Chau KY, Schapira AH.
Pryde KR, et al.
J Cell Biol. 2016 Apr 25;213(2):163-71. doi: 10.1083/jcb.201509003. Epub 2016 Apr 18.
J Cell Biol. 2016.
PMID: 27091447
Free PMC article.
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A comparative cell biological analysis reveals only limited functional homology between the NS5A proteins of hepatitis C virus and GB virus B.
Mankouri J, Milward A, Pryde KR, Warter L, Martin A, Harris M.
Mankouri J, et al. Among authors: pryde kr.
J Gen Virol. 2008 Aug;89(Pt 8):1911-1920. doi: 10.1099/vir.0.2008/001131-0.
J Gen Virol. 2008.
PMID: 18632962
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