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Page 1
Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
Venier O, Pascal C, Braun A, Namane C, Mougenot P, Crespin O, Pacquet F, Mougenot C, Monseau C, Onofri B, Dadji-Faïhun R, Leger C, Ben-Hassine M, Van-Pham T, Ragot JL, Philippo C, Farjot G, Noah L, Maniani K, Boutarfa A, Nicolaï E, Guillot E, Pruniaux MP, Güssregen S, Engel C, Coutant AL, de Miguel B, Castro A. Venier O, et al. Among authors: pruniaux mp. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2414-21. doi: 10.1016/j.bmcl.2013.02.018. Epub 2013 Feb 22. Bioorg Med Chem Lett. 2013. PMID: 23478147
Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1.
Mougenot P, Namane C, Fett E, Camy F, Dadji-Faïhun R, Langot G, Monseau C, Onofri B, Pacquet F, Pascal C, Crespin O, Ben-Hassine M, Ragot JL, Van-Pham T, Philippo C, Chatelain-Egger F, Péron P, Le Bail JC, Guillot E, Chamiot-Clerc P, Chabanaud MA, Pruniaux MP, Schmidt F, Venier O, Nicolaï E, Viviani F. Mougenot P, et al. Among authors: pruniaux mp. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2497-502. doi: 10.1016/j.bmcl.2012.02.006. Epub 2012 Feb 15. Bioorg Med Chem Lett. 2012. PMID: 22405833
Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors.
Mougenot P, Namane C, Fett E, Goumy F, Dadji-Faïhun R, Langot G, Monseau C, Onofri B, Pacquet F, Pascal C, Crespin O, Ben-Hassine M, Ragot JL, Van-Pham T, Philippo C, Chatelain-Egger F, Péron P, Le Bail JC, Guillot E, Chamiot-Clerc P, Chabanaud MA, Pruniaux MP, Ménegotto J, Schmidt F, Venier O, Viviani F, Nicolai E. Mougenot P, et al. Among authors: pruniaux mp. Bioorg Med Chem Lett. 2016 Jan 1;26(1):25-32. doi: 10.1016/j.bmcl.2015.11.046. Epub 2015 Nov 25. Bioorg Med Chem Lett. 2016. PMID: 26627579
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).
Gao Z, Hurst WJ, Guillot E, Czechtizky W, Lukasczyk U, Nagorny R, Pruniaux MP, Schwink L, Sanchez JA, Stengelin S, Tang L, Winkler I, Hendrix JA, George PG. Gao Z, et al. Among authors: pruniaux mp. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3416-20. doi: 10.1016/j.bmcl.2013.03.080. Epub 2013 Mar 29. Bioorg Med Chem Lett. 2013. PMID: 23591110
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part II).
Gao Z, Hurst WJ, Guillot E, Czechtizky W, Lukasczyk U, Nagorny R, Pruniaux MP, Schwink L, Sanchez JA, Stengelin S, Tang L, Winkler I, Hendrix JA, George PG. Gao Z, et al. Among authors: pruniaux mp. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3421-6. doi: 10.1016/j.bmcl.2013.03.081. Epub 2013 Mar 28. Bioorg Med Chem Lett. 2013. PMID: 23591112
Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide.
Gao Z, Hurst WJ, Guillot E, Nagorny R, Pruniaux MP, Hendrix JA, George PG. Gao Z, et al. Among authors: pruniaux mp. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4044-7. doi: 10.1016/j.bmcl.2013.05.068. Epub 2013 May 30. Bioorg Med Chem Lett. 2013. PMID: 23769643
SAR110894, a potent histamine H₃-receptor antagonist, displays procognitive effects in rodents.
Griebel G, Pichat P, Pruniaux MP, Beeské S, Lopez-Grancha M, Genet E, Terranova JP, Castro A, Sánchez JA, Black M, Varty GB, Weiner I, Arad M, Barak S, De Levie A, Guillot E. Griebel G, et al. Among authors: pruniaux mp. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14. doi: 10.1016/j.pbb.2012.04.004. Epub 2012 Apr 21. Pharmacol Biochem Behav. 2012. PMID: 22542742
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.
Beauverger P, Ozoux ML, Bégis G, Glénat V, Briand V, Philippo MC, Daveu C, Tavares G, Roy S, Corbier A, Briand P, Dorchies O, Bauchet AL, Nicolai E, Duclos O, Tamarelle D, Pruniaux MP, Muslin AJ, Janiak P. Beauverger P, et al. Among authors: pruniaux mp. Cardiovasc Res. 2020 Feb 1;116(2):329-338. doi: 10.1093/cvr/cvz097. Cardiovasc Res. 2020. PMID: 31038167
The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice.
Pang Z, Wu NN, Zhao W, Chain DC, Schaffer E, Zhang X, Yamdagni P, Palejwala VA, Fan C, Favara SG, Dressler HM, Economides KD, Weinstock D, Cavallo JS, Naimi S, Galzin AM, Guillot E, Pruniaux MP, Tocci MJ, Polites HG. Pang Z, et al. Among authors: pruniaux mp. Obesity (Silver Spring). 2011 Oct;19(10):1923-34. doi: 10.1038/oby.2011.250. Epub 2011 Jul 28. Obesity (Silver Spring). 2011. PMID: 21799481 Free article.
24 results