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Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches.
Soleilhac E, Brillet-Guéguen L, Roussel V, Prudent R, Touquet B, Dass S, Aci-Sèche S, Kasam V, Barette C, Imberty A, Breton V, Vantard M, Horvath D, Botté C, Tardieux I, Roy S, Maréchal E, Lafanechère L. Soleilhac E, et al. Among authors: prudent r. Int J Mol Sci. 2018 Oct 9;19(10):3085. doi: 10.3390/ijms19103085. Int J Mol Sci. 2018. PMID: 30304836 Free PMC article.
Novel synthetic pharmacophores inducing a stabilization of cellular microtubules.
Martinez A, Soleilhac E, Barette C, Prudent R, Gozzi GJ, Vassal-Stermann E, Pillet C, Di Pietro A, Fauvarque MO, Lafanechere L. Martinez A, et al. Among authors: prudent r. Curr Cancer Drug Targets. 2015;15(1):2-13. doi: 10.2174/1568009615666141215154149. Curr Cancer Drug Targets. 2015. PMID: 25543663
Expanding the chemical diversity of CK2 inhibitors.
Prudent R, Moucadel V, López-Ramos M, Aci S, Laudet B, Mouawad L, Barette C, Einhorn J, Einhorn C, Denis JN, Bisson G, Schmidt F, Roy S, Lafanechere L, Florent JC, Cochet C. Prudent R, et al. Mol Cell Biochem. 2008 Sep;316(1-2):71-85. doi: 10.1007/s11010-008-9828-z. Epub 2008 Jun 18. Mol Cell Biochem. 2008. PMID: 18563535
Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities.
Prudent R, Vassal-Stermann É, Nguyen CH, Mollaret M, Viallet J, Desroches-Castan A, Martinez A, Barette C, Pillet C, Valdameri G, Soleilhac E, Di Pietro A, Feige JJ, Billaud M, Florent JC, Lafanechère L. Prudent R, et al. Br J Pharmacol. 2013 Feb;168(3):673-85. doi: 10.1111/j.1476-5381.2012.02230.x. Br J Pharmacol. 2013. PMID: 23004938 Free PMC article.
Antitumoral activity of allosteric inhibitors of protein kinase CK2.
Moucadel V, Prudent R, Sautel CF, Teillet F, Barette C, Lafanechere L, Receveur-Brechot V, Cochet C. Moucadel V, et al. Among authors: prudent r. Oncotarget. 2011 Dec;2(12):997-1010. doi: 10.18632/oncotarget.361. Oncotarget. 2011. PMID: 22184283 Free PMC article.
Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.
Prudent R, Vassal-Stermann E, Nguyen CH, Pillet C, Martinez A, Prunier C, Barette C, Soleilhac E, Filhol O, Beghin A, Valdameri G, Honoré S, Aci-Sèche S, Grierson D, Antonipillai J, Li R, Di Pietro A, Dumontet C, Braguer D, Florent JC, Knapp S, Bernard O, Lafanechère L. Prudent R, et al. Cancer Res. 2012 Sep 1;72(17):4429-39. doi: 10.1158/0008-5472.CAN-11-3342. Epub 2012 Jul 3. Cancer Res. 2012. PMID: 22761334 Free article.
LIM kinases: cofilin and beyond.
Prunier C, Prudent R, Kapur R, Sadoul K, Lafanechère L. Prunier C, et al. Among authors: prudent r. Oncotarget. 2017 Jun 20;8(25):41749-41763. doi: 10.18632/oncotarget.16978. Oncotarget. 2017. PMID: 28445157 Free PMC article. Review.
Salicylaldehyde derivatives as new protein kinase CK2 inhibitors.
Prudent R, López-Ramos M, Moucadel V, Barette C, Grierson D, Mouawad L, Florent JC, Lafanechère L, Schmidt F, Cochet C. Prudent R, et al. Biochim Biophys Acta. 2008 Dec;1780(12):1412-20. doi: 10.1016/j.bbagen.2008.06.010. Epub 2008 Jul 7. Biochim Biophys Acta. 2008. PMID: 18674590
36 results