Prothon S - Search Results

1

AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study.

van Laar JM, Lei A, Safy-Khan M, Almquist J, Belfield G, Edman K, Öberg L, Angermann BR, Dillmann I, Berntsson P, Etal D, Dainty I, Astbury C, Belvisi MG, Nemes S, Platt A, Prothon S, Samuelsson S, Svanberg P, Keen C; SEMRA study group. van Laar JM, et al. Among authors: prothon s. Clin Transl Sci. 2023 Dec;16(12):2494-2506. doi: 10.1111/cts.13624. Epub 2023 Oct 23. Clin Transl Sci. 2023. PMID: 37873558 Free PMC article. Clinical Trial.

2

Estimation of Equipotent Doses for Anti-Inflammatory Effects of Prednisolone and AZD9567, an Oral Selective Nonsteroidal Glucocorticoid Receptor Modulator.

Almquist J, Sadiq MW, Eriksson UG, Hegelund Myrbäck T, Prothon S, Leander J. Almquist J, et al. Among authors: prothon s. CPT Pharmacometrics Syst Pharmacol. 2020 Aug;9(8):444-455. doi: 10.1002/psp4.12536. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32501650 Free PMC article.

3

Efficacy and Tolerability of an Inhaled Selective Glucocorticoid Receptor Modulator - AZD5423 - in Chronic Obstructive Pulmonary Disease Patients: Phase II Study Results.

Kuna P, Aurivillius M, Jorup C, Prothon S, Taib Z, Edsbäcker S. Kuna P, et al. Among authors: prothon s. Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):279-289. doi: 10.1111/bcpt.12768. Epub 2017 Jul 17. Basic Clin Pharmacol Toxicol. 2017. PMID: 28212463 Free article. Clinical Trial.

4

Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Velsecorat (AZD7594) Following Inhalation in Healthy Volunteers.

Prothon S, Aurivillius M, Tehler U, Eriksson UG, Aggarwal A, Chen Y. Prothon S, et al. Drug Des Devel Ther. 2022 Feb 23;16:485-497. doi: 10.2147/DDDT.S334960. eCollection 2022. Drug Des Devel Ther. 2022. PMID: 35264846 Free PMC article. Clinical Trial.

5

Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator AZD5423 after Inhalation in Healthy Volunteers.

Werkström V, Prothon S, Ekholm E, Jorup C, Edsbäcker S. Werkström V, et al. Among authors: prothon s. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581. doi: 10.1111/bcpt.12621. Epub 2016 Jul 8. Basic Clin Pharmacol Toxicol. 2016. PMID: 27214145 Free article. Clinical Trial.

6

Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers.

Prothon S, Wählby Hamrén U, Tehler U, Yoon E, Forsman H, Arfvidsson C, Aggarwal A, Chen Y. Prothon S, et al. Drug Des Devel Ther. 2019 Nov 12;13:3845-3853. doi: 10.2147/DDDT.S215170. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31814707 Free PMC article. Clinical Trial.

7

Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure-Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects.

Palmér R, Mäenpää J, Jauhiainen A, Larsson B, Mo J, Russell M, Root J, Prothon S, Chialda L, Forte P, Egelrud T, Stenvall K, Gardiner P. Palmér R, et al. Among authors: prothon s. Clin Pharmacol Ther. 2018 Dec;104(6):1155-1164. doi: 10.1002/cpt.1053. Epub 2018 Apr 16. Clin Pharmacol Ther. 2018. PMID: 29484635 Free PMC article. Clinical Trial.

8

Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects.

Holmberg AA, Weidolf L, Necander S, Bold P, Sidhu S, Pelay-Gimeno M, de Ligt RAF, Verheij ER, Jauhiainen A, Psallidas I, Wählby Hamrén U, Prothon S. Holmberg AA, et al. Among authors: prothon s. Drug Metab Dispos. 2022 Feb;50(2):150-157. doi: 10.1124/dmd.121.000632. Epub 2021 Dec 1. Drug Metab Dispos. 2022. PMID: 34853068

9

Pharmacokinetics of the Inhaled Selective Glucocorticoid Receptor Modulator AZD5423 Following Inhalation Using Different Devices.

Melin J, Prothon S, Kloft C, Cleton A, Amilon C, Jorup C, Bäckman P, Olsson B, Hamrén UW. Melin J, et al. Among authors: prothon s. AAPS J. 2017 May;19(3):865-874. doi: 10.1208/s12248-016-0042-8. Epub 2017 Mar 9. AAPS J. 2017. PMID: 28281196 Clinical Trial.

10

The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.

Ambery P, Zajac G, Almquist J, Prothon S, Astbury C, Brown MN, Nemes S, Nsabimana J, Edman K, Öberg L, Lepistö M, Edenro G, Dillmann I, Mitra S, Belfield G, Keen C, Heise T. Ambery P, et al. Among authors: prothon s. Br J Clin Pharmacol. 2024 May 1. doi: 10.1111/bcp.16082. Online ahead of print. Br J Clin Pharmacol. 2024. PMID: 38690606

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