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2022 | 1 |
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Genetic predisposition to mosaic Y chromosome loss in blood.
Nature. 2019 Nov;575(7784):652-657. doi: 10.1038/s41586-019-1765-3. Epub 2019 Nov 20.
Nature. 2019.
PMID: 31748747
Free PMC article.
Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. ...These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as som …
Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) h …
Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk.
Yarmolinsky J, Amos CI, Hung RJ, Moreno V, Burrows K, Smith-Byrne K, Atkins JR, Brennan P; Colon Cancer Family Registry (CCFR), Colorectal Cancer Transdisciplinary Study (CORECT), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium; McKay JD, Martin RM, Davey Smith G.
Yarmolinsky J, et al.
Int J Cancer. 2022 Dec 15;151(12):2155-2160. doi: 10.1002/ijc.34180. Epub 2022 Jul 9.
Int J Cancer. 2022.
PMID: 35747941
Free PMC article.
We used a partial loss-of-function variant in TYK2 (rs34536443), previously shown to protect against psoriasis and other autoimmune diseases, to evaluate the potential effect of therapeutic TYK2 inhibition on risk of lung cancer and non-Hodgkin lymphoma. Summary genetic …
We used a partial loss-of-function variant in TYK2 (rs34536443), previously shown to protect against psoriasis and other autoimmune diseases …
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