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Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands.
Staquicini DI, Cardó-Vila M, Rotolo JA, Staquicini FI, Tang FHF, Smith TL, Ganju A, Schiavone C, Dogra P, Wang Z, Cristini V, Giordano RJ, Ozawa MG, Driessen WHP, Proneth B, Souza GR, Brinker LM, Noureddine A, Snider AJ, Canals D, Gelovani JG, Petrache I, Tuder RM, Obeid LM, Hannun YA, Kolesnick RN, Brinker CJ, Pasqualini R, Arap W. Staquicini DI, et al. Among authors: proneth b. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2220269120. doi: 10.1073/pnas.2220269120. Epub 2023 Aug 14. Proc Natl Acad Sci U S A. 2023. PMID: 37579172 Free PMC article.
Phase separation of FSP1 promotes ferroptosis.
Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M. Nakamura T, et al. Among authors: proneth b. Nature. 2023 Jul;619(7969):371-377. doi: 10.1038/s41586-023-06255-6. Epub 2023 Jun 28. Nature. 2023. PMID: 37380771 Free PMC article.
Activation of lysosomal iron triggers ferroptosis in cancer.
Rodriguez R, Cañeque T, Baron L, Müller S, Carmona A, Colombeau L, Versini A, Sabatier M, Sampaio J, Mishima E, Picard-Bernes A, Solier S, Zheng J, Proneth B, Thoidingjam L, Gaillet C, Grimaud L, Fraser C, Szylo K, Bonnet C, Charafe E, Ginestier C, Santofimia P, Dusetti N, Iovanna J, Sa Cunha A, Pittau G, Hammel P, Tzanis D, Bonvalot S, Watson S, Stockwell B, Conrad M, Ubellacker J. Rodriguez R, et al. Among authors: proneth b. Res Sq [Preprint]. 2024 Apr 8:rs.3.rs-4165774. doi: 10.21203/rs.3.rs-4165774/v1. Res Sq. 2024. PMID: 38659936 Free PMC article. Preprint.
Chains of death.
Zheng J, Proneth B. Zheng J, et al. Among authors: proneth b. Nat Chem Biol. 2024 Feb 6. doi: 10.1038/s41589-023-01541-w. Online ahead of print. Nat Chem Biol. 2024. PMID: 38321207 No abstract available.
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.
Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M. Nakamura T, et al. Among authors: proneth b. Nat Struct Mol Biol. 2023 Nov;30(11):1806-1815. doi: 10.1038/s41594-023-01136-y. Epub 2023 Nov 13. Nat Struct Mol Biol. 2023. PMID: 37957306 Free PMC article.
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Mishima E, et al. Among authors: proneth b. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. Nature. 2022. PMID: 35922516 Free PMC article.
NFE2L1-mediated proteasome function protects from ferroptosis.
Kotschi S, Jung A, Willemsen N, Ofoghi A, Proneth B, Conrad M, Bartelt A. Kotschi S, et al. Among authors: proneth b. Mol Metab. 2022 Mar;57:101436. doi: 10.1016/j.molmet.2022.101436. Epub 2022 Jan 6. Mol Metab. 2022. PMID: 34999280 Free PMC article.
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother PJ, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, Kreisel D, Pratt D, Gütschow M, Conrad M, Linkermann A. Tonnus W, et al. Among authors: proneth b. Nat Commun. 2021 Jul 20;12(1):4402. doi: 10.1038/s41467-021-24712-6. Nat Commun. 2021. PMID: 34285231 Free PMC article.
36 results