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DKK1-CKAP4 signal axis promotes hepatocellular carcinoma aggressiveness.
Iguchi K, Sada R, Matsumoto S, Kimura H, Zen Y, Akita M, Gon H, Fukumoto T, Kikuchi A. Iguchi K, et al. Cancer Sci. 2023 May;114(5):2063-2077. doi: 10.1111/cas.15743. Epub 2023 Mar 9. Cancer Sci. 2023. PMID: 36718957 Free PMC article.
Anti-CKAP4 Ab inhibited HCC growth, and its antitumor effect was clearly enhanced when combined with lenvatinib, a multikinase inhibitor. These results indicate that simultaneous expression of DKK1 and CKAP4 is involved in the aggressiveness of HCC, and that the combinatio …
Anti-CKAP4 Ab inhibited HCC growth, and its antitumor effect was clearly enhanced when combined with lenvatinib, a multikinase inhibi …
Therapy-resistant nature of cancer stem cells in view of iron metabolism.
Wang W, Tabu K, Aimaitijiang A, Taga T. Wang W, et al. Inflamm Regen. 2022 Nov 3;42(1):34. doi: 10.1186/s41232-022-00220-y. Inflamm Regen. 2022. PMID: 36324180 Free PMC article. Review.
Due to increased resistance to standard chemo/radiotherapies and relapse, highly tumorigenic cancer stem cells (CSCs) have been proposed as a promising target for the development of effective cancer treatments. ...Potential treatment options targeting iron ho …
Due to increased resistance to standard chemo/radiotherapies and relapse, highly tumorigenic cancer stem cells (CSCs) have been propo …
Cancer-associated miRNAs and their therapeutic potential.
Inoue J, Inazawa J. Inoue J, et al. J Hum Genet. 2021 Sep;66(9):937-945. doi: 10.1038/s10038-021-00938-6. Epub 2021 Jun 4. J Hum Genet. 2021. PMID: 34088973 Review.
MicroRNA (miRNA; miR) is a functionally small non-coding RNA and can negatively regulate gene expression by directly binding to the target gene. Some miRNAs are closely involved in the development and progression of cancer and are abnormally expressed in many can …
MicroRNA (miRNA; miR) is a functionally small non-coding RNA and can negatively regulate gene expression by directly binding to the target g …
Enhanced anti-tumor effects of the PD-1 blockade combined with a highly absorptive form of curcumin targeting STAT3.
Hayakawa T, Yaguchi T, Kawakami Y. Hayakawa T, et al. Cancer Sci. 2020 Dec;111(12):4326-4335. doi: 10.1111/cas.14675. Epub 2020 Oct 20. Cancer Sci. 2020. PMID: 33006786 Free PMC article.
PD-1/PD-L1 immune checkpoint inhibitors are promising cancer immunotherapies however responses are still limited and the development of more effective combination immunotherapy is needed. We previously reported that STAT3 activation in cancer cells and immune …
PD-1/PD-L1 immune checkpoint inhibitors are promising cancer immunotherapies however responses are still limited and the developme …
Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives.
Miyai Y, Esaki N, Takahashi M, Enomoto A. Miyai Y, et al. Cancer Sci. 2020 Apr;111(4):1047-1057. doi: 10.1111/cas.14346. Epub 2020 Mar 10. Cancer Sci. 2020. PMID: 32060987 Free PMC article. Review.
Their contribution to therapeutic resistance is also well appreciated. Therefore, CAF have been considered as a therapeutic target in cancer. ...While cancer-promoting CAF (pCAF) have been extensively studied, the nature and specific marker(s) of ca …
Their contribution to therapeutic resistance is also well appreciated. Therefore, CAF have been considered as a therapeutic ta …
NOTCH1 pathway activating mutations and clonal evolution in pediatric T-cell acute lymphoblastic leukemia.
Kimura S, Seki M, Yoshida K, Shiraishi Y, Akiyama M, Koh K, Imamura T, Manabe A, Hayashi Y, Kobayashi M, Oka A, Miyano S, Ogawa S, Takita J. Kimura S, et al. Cancer Sci. 2019 Feb;110(2):784-794. doi: 10.1111/cas.13859. Epub 2019 Jan 9. Cancer Sci. 2019. PMID: 30387229 Free PMC article.
To unravel the relevance of NOTCH1/FBXW7 mutations associated with relapse, we performed whole-exome sequencing in 30 pediatric T-ALL cases, among which 11 diagnosis-relapse paired cases were further investigated to track the clonal evolution of relapse using amplicon-base …
To unravel the relevance of NOTCH1/FBXW7 mutations associated with relapse, we performed whole-exome sequencing in 30 pediatric T-ALL cases, …
Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis.
Ikeno Y, Seo S, Iwaisako K, Yoh T, Nakamoto Y, Fuji H, Taura K, Okajima H, Kaido T, Sakaguchi S, Uemoto S. Ikeno Y, et al. J Transl Med. 2018 Apr 11;16(1):95. doi: 10.1186/s12967-018-1475-x. J Transl Med. 2018. PMID: 29642912 Free PMC article.
Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical management. Despite developments in the molecular profiling of ICC, the preoperative prediction of prognosis remains a challenge. ...
Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical management. Despite developments …
Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer.
Honda K, Srivastava S. Honda K, et al. Biomark Med. 2016 Nov;10(11):1197-1207. doi: 10.2217/bmm-2016-0209. Epub 2016 Sep 27. Biomark Med. 2016. PMID: 27673558 Free PMC article. Review.
Given the low incidence of pancreatic cancer in the general population, screening of pancreatic cancer in the general population using invasive modalities is not feasible. Combination of invasive screening with noninvasive biomarkers for pancreatic cancer and …
Given the low incidence of pancreatic cancer in the general population, screening of pancreatic cancer in the general populati …