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Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif.
Désiré J, Foucart Q, Poveda A, Gourlaouen G, Shimadate Y, Kise M, Proceviat C, Ashmus R, Vocadlo DJ, Jiménez-Barbero J, Kato A, Blériot Y. Désiré J, et al. Among authors: proceviat c. Carbohydr Res. 2022 Jan;511:108491. doi: 10.1016/j.carres.2021.108491. Epub 2021 Dec 20. Carbohydr Res. 2022. PMID: 34953389 Free article.
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors.
Bouquet J, Auberger N, Ashmus R, King D, Bordes A, Fontelle N, Nakagawa S, Madden Z, Proceviat C, Kato A, Désiré J, Vocadlo DJ, Blériot Y. Bouquet J, et al. Among authors: proceviat c. Org Biomol Chem. 2022 Jan 19;20(3):619-629. doi: 10.1039/d1ob02280f. Org Biomol Chem. 2022. PMID: 34940771
Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications.
González-Cuesta M, Sidhu P, Ashmus RA, Males A, Proceviat C, Madden Z, Rogalski JC, Busmann JA, Foster LJ, García Fernández JM, Davies GJ, Ortiz Mellet C, Vocadlo DJ. González-Cuesta M, et al. Among authors: proceviat c. J Am Chem Soc. 2022 Jan 19;144(2):832-844. doi: 10.1021/jacs.1c10504. Epub 2022 Jan 5. J Am Chem Soc. 2022. PMID: 34985906
A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae.
Bhosale S, Deen MC, Proceviat C, Hettle A, Winter DK, Brockerman J, Levene M, Bennet AJ, Spino C, Boraston AB, Vocadlo DJ. Bhosale S, et al. Among authors: proceviat c. ACS Chem Biol. 2023 Aug 18;18(8):1730-1737. doi: 10.1021/acschembio.3c00053. Epub 2023 Aug 2. ACS Chem Biol. 2023. PMID: 37531094