Prnova MS - Search Results

1

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications.

Kovacikova L, Prnova MS, Majekova M, Bohac A, Karasu C, Stefek M. Kovacikova L, et al. Among authors: prnova ms. Molecules. 2021 May 12;26(10):2867. doi: 10.3390/molecules26102867. Molecules. 2021. PMID: 34066081 Free PMC article. Review.

2

Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation.

Chatzopoulou M, Patsilinakos A, Vallianatou T, Prnova MS, Zakelj S, Ragno R, Stefek M, Kristl A, Tsantili-Kakoulidou A, Demopoulos VJ. Chatzopoulou M, et al. Among authors: prnova ms. Bioorg Med Chem. 2014 Apr 1;22(7):2194-207. doi: 10.1016/j.bmc.2014.02.016. Epub 2014 Feb 26. Bioorg Med Chem. 2014. PMID: 24630695

3

2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent.

Milackova I, Prnova MS, Majekova M, Sotnikova R, Stasko M, Kovacikova L, Banerjee S, Veverka M, Stefek M. Milackova I, et al. Among authors: prnova ms. J Enzyme Inhib Med Chem. 2015 Feb;30(1):107-13. doi: 10.3109/14756366.2014.892935. Epub 2014 Mar 25. J Enzyme Inhib Med Chem. 2015. PMID: 24666303

4

A novel zwitterionic inhibitor of aldose reductase interferes with polyol pathway in ex vivo and in vivo models of diabetic complications.

Karasova MJ, Prnova MS, Stefek M. Karasova MJ, et al. Among authors: prnova ms. Pharmazie. 2014 Oct;69(10):747-51. Pharmazie. 2014. PMID: 25985564

5

Antioxidant action of 3-mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid, an efficient aldose reductase inhibitor, in a 1,1'-diphenyl-2-picrylhydrazyl assay and in the cellular system of isolated erythrocytes exposed to tert-butyl hydroperoxide.

Prnova MS, Ballekova J, Majekova M, Stefek M. Prnova MS, et al. Redox Rep. 2015;20(6):282-8. doi: 10.1179/1351000215Y.0000000019. Epub 2015 Jun 11. Redox Rep. 2015. PMID: 26066740 Free PMC article.

6

Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases.

Zizkova P, Stefek M, Rackova L, Prnova M, Horakova L. Zizkova P, et al. Chem Biol Interact. 2017 Mar 1;265:36-46. doi: 10.1016/j.cbi.2017.01.019. Epub 2017 Jan 28. Chem Biol Interact. 2017. PMID: 28137512 Review.

7

Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity.

Majekova M, Ballekova J, Prnova M, Stefek M. Majekova M, et al. Bioorg Med Chem. 2017 Dec 15;25(24):6353-6360. doi: 10.1016/j.bmc.2017.10.005. Epub 2017 Oct 16. Bioorg Med Chem. 2017. PMID: 29074349

8

Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat-another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats.

Prnova MS, Kovacikova L, Svik K, Bezek S, Elmazoğlu Z, Karasu C, Stefek M. Prnova MS, et al. Naunyn Schmiedebergs Arch Pharmacol. 2020 Apr;393(4):651-661. doi: 10.1007/s00210-019-01769-1. Epub 2019 Dec 5. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 31802170

9

Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity.

Hlaváč M, Kováčiková L, Prnová MŠ, Šramel P, Addová G, Májeková M, Hanquet G, Boháč A, Štefek M. Hlaváč M, et al. Among authors: prnova ms. J Med Chem. 2020 Jan 9;63(1):369-381. doi: 10.1021/acs.jmedchem.9b01747. Epub 2019 Dec 30. J Med Chem. 2020. PMID: 31820975

10

General toxicity assessment of the novel aldose reductase inhibitor cemtirestat.

Prnová MŠ, Račková L, Kováčiková L, Balleková J, Viskupičová J, Micháliková S, Taşkoparan B, Elmazoğlu Z, Rižner TL, Karasu C, Banerjee S, Štefek M. Prnová MŠ, et al. Interdiscip Toxicol. 2019 Nov;12(3):120-128. doi: 10.2478/intox-2019-0014. Epub 2020 Feb 20. Interdiscip Toxicol. 2019. PMID: 32210700 Free PMC article.

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