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Year Number of Results
1912 1
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1917 2
1918 2
1919 2
1920 1
1922 1
1924 1
1925 1
1929 1
1930 1
1931 1
1934 1
1935 1
1936 1
1939 1
1940 3
1942 2
1943 1
1944 1
1945 32
1946 110
1947 146
1948 154
1949 156
1950 210
1951 307
1952 392
1953 425
1954 442
1955 444
1956 440
1957 505
1958 524
1959 695
1960 868
1961 880
1962 1054
1963 1637
1964 2184
1965 1857
1966 2068
1967 2540
1968 3098
1969 3482
1970 3579
1971 4163
1972 4621
1973 4794
1974 5218
1975 4946
1976 4912
1977 4753
1978 4608
1979 5283
1980 5476
1981 5516
1982 5837
1983 6409
1984 6824
1985 7252
1986 7601
1987 7418
1988 7828
1989 8316
1990 8675
1991 9292
1992 9362
1993 9336
1994 9889
1995 10397
1996 10931
1997 11505
1998 12377
1999 13080
2000 14378
2001 15114
2002 15803
2003 17296
2004 18002
2005 19075
2006 20210
2007 21091
2008 21682
2009 21946
2010 22902
2011 23646
2012 24762
2013 24845
2014 24260
2015 23958
2016 22860
2017 21870
2018 20768
2019 20392
2020 23101
2021 22599
2022 21966
2023 18608
2024 6884

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695,704 results

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Page 1
Showing results for protease a
Search for Prioteasa A instead (1 results)
[Key active sites of proteases and protease inhibitors: a review].
Zhang J, Yang X, Li Y. Zhang J, et al. Sheng Wu Gong Cheng Xue Bao. 2021 Feb 25;37(2):561-579. doi: 10.13345/j.cjb.200579. Sheng Wu Gong Cheng Xue Bao. 2021. PMID: 33645155 Review. Chinese.
More active, stable, specific, environmentally friendly and cheap proteases and protease inhibitors might be obtained by excavating various natural mutants of proteases and protease inhibitors, analyzing their key active sites by using protein engineer …
More active, stable, specific, environmentally friendly and cheap proteases and protease inhibitors might be obtained by excav …
Cleaving for growth: threonine aspartase 1--a protease relevant for development and disease.
Stauber RH, Hahlbrock A, Knauer SK, Wünsch D. Stauber RH, et al. FASEB J. 2016 Mar;30(3):1012-22. doi: 10.1096/fj.15-270611. Epub 2015 Nov 17. FASEB J. 2016. PMID: 26578689 Review.
From the beginning of life, proteases are key to organismal development comprising morphogenesis, cellular differentiation, and cell growth. Regulated proteolytic activity is essential for the orchestration of multiple developmental pathways, and defects in protease …
From the beginning of life, proteases are key to organismal development comprising morphogenesis, cellular differentiation, and cell …
Designed protease-based signaling networks.
Fink T, Jerala R. Fink T, et al. Curr Opin Chem Biol. 2022 Jun;68:102146. doi: 10.1016/j.cbpa.2022.102146. Epub 2022 Apr 14. Curr Opin Chem Biol. 2022. PMID: 35430555 Free article. Review.
Regulated proteolysis is a pivotal regulatory mechanism in all living organisms from bacteria to mammalian cells and viruses. The ability to design proteases to sense, transmit, or trigger a signal opens up the possibility of construction of sophisticated proteolysis-regul …
Regulated proteolysis is a pivotal regulatory mechanism in all living organisms from bacteria to mammalian cells and viruses. The ability to …
Disruption of protease A and B orthologous genes in the basidiomycetous yeast Pseudozyma antarctica GB-4(0) yields a stable extracellular biodegradable plastic-degrading enzyme.
Omae N, Sameshima-Yamashita Y, Ushimaru K, Koike H, Kitamoto H, Morita T. Omae N, et al. PLoS One. 2021 Mar 17;16(3):e0247462. doi: 10.1371/journal.pone.0247462. eCollection 2021. PLoS One. 2021. PMID: 33730094 Free PMC article.
To suppress degradation of PaE during production and storage, we targeted the inhibition of proteolytic enzyme activity in P. antarctica. Proteases A and B act as upper regulators in the proteolytic network of the model yeast, Saccharomyces cerevisiae. We searched for orth …
To suppress degradation of PaE during production and storage, we targeted the inhibition of proteolytic enzyme activity in P. antarctica. …
Auto- and Hetero-Catalytic Processing of the N-Terminal Propeptide Promotes the C-Terminal Fibronectin Type III Domain-Mediated Dimerization of a Thermostable Vpr-like Protease.
Huang Q, Zhang K, Li Y, Gan F, Tang XF, Tang B. Huang Q, et al. Appl Environ Microbiol. 2022 Nov 8;88(21):e0150322. doi: 10.1128/aem.01503-22. Epub 2022 Oct 17. Appl Environ Microbiol. 2022. PMID: 36250702 Free PMC article.
The BTV precursor comprises a signal peptide, an N-terminal propeptide, a subtilisin-like catalytic domain with an inserted protease-associated (PA) domain, two tandem fibronectin type III domains (Fn1 and Fn2), and a C-terminal propeptide. ...The dissection of the …
The BTV precursor comprises a signal peptide, an N-terminal propeptide, a subtilisin-like catalytic domain with an inserted protea …
USP18 - a multifunctional component in the interferon response.
Basters A, Knobeloch KP, Fritz G. Basters A, et al. Biosci Rep. 2018 Nov 15;38(6):BSR20180250. doi: 10.1042/BSR20180250. Print 2018 Dec 21. Biosci Rep. 2018. PMID: 30126853 Free PMC article. Review.
Ubiquitin-specific proteases (USPs) represent the largest family of deubiquitinating enzymes (DUB). These proteases cleave the isopeptide bond between ubiquitin and a lysine residue of a ubiquitin-modified protein. ...
Ubiquitin-specific proteases (USPs) represent the largest family of deubiquitinating enzymes (DUB). These proteases cleave the …
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity.
Poreba M, Salvesen GS, Drag M. Poreba M, et al. Nat Protoc. 2017 Oct;12(10):2189-2214. doi: 10.1038/nprot.2017.091. Epub 2017 Sep 21. Nat Protoc. 2017. PMID: 28933778
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates and probes. It is, however, difficult to find substrate sequences that are truly selective for any given protease, as different proteas …
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates and p …
A protease-resistant protein is a structural component of the scrapie prion.
McKinley MP, Bolton DC, Prusiner SB. McKinley MP, et al. Cell. 1983 Nov;35(1):57-62. doi: 10.1016/0092-8674(83)90207-6. Cell. 1983. PMID: 6414721
Prolonging the digestion resulted in a concomitant decrease in both PrP and the scrapie prion. When the amino-acid-specific proteases trypsin or SV-8 protease were used instead of proteinase K, no change in either PrP or the prion was detected. ...
Prolonging the digestion resulted in a concomitant decrease in both PrP and the scrapie prion. When the amino-acid-specific proteases …
Looking at the proteases from a simple perspective.
Castro HC, Abreu PA, Geraldo RB, Martins RC, dos Santos R, Loureiro NI, Cabral LM, Rodrigues CR. Castro HC, et al. J Mol Recognit. 2011 Mar-Apr;24(2):165-81. doi: 10.1002/jmr.1091. J Mol Recognit. 2011. PMID: 21360607 Review.
Many efforts has been undertaken to design effective inhibitors featuring potent inhibitory activity, specificity, and metabolic stability to those proteases involved in such pathologies. Protease inhibitors usually target the active site, but some of them act by ot …
Many efforts has been undertaken to design effective inhibitors featuring potent inhibitory activity, specificity, and metabolic stability t …
Maturation Process and Characterization of a Novel Thermostable and Halotolerant Subtilisin-Like Protease with High Collagenolytic Activity but Low Gelatinolytic Activity.
Zhang K, Huang Q, Li Y, Liu L, Tang XF, Tang B. Zhang K, et al. Appl Environ Microbiol. 2022 Feb 8;88(3):e0218421. doi: 10.1128/aem.02184-21. Epub 2021 Dec 1. Appl Environ Microbiol. 2022. PMID: 35133860 Free PMC article.
Enzymatic degradation of collagen is of great industrial and environmental significance; however, little is known about thermophile-derived collagenolytic proteases. Here, we report a novel collagenolytic protease (TSS) from thermophilic Brevibacillus sp. ...Our res …
Enzymatic degradation of collagen is of great industrial and environmental significance; however, little is known about thermophile-derived …
695,704 results
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