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Type III-B CRISPR-Cas cascade of proteolytic cleavages.
Steens JA, Bravo JPK, Salazar CRP, Yildiz C, Amieiro AM, Köstlbacher S, Prinsen SHP, Andres AS, Patinios C, Bardis A, Barendregt A, Scheltema RA, Ettema TJG, van der Oost J, Taylor DW, Staals RHJ. Steens JA, et al. Among authors: prinsen shp. Science. 2024 Feb 2;383(6682):512-519. doi: 10.1126/science.adk0378. Epub 2024 Feb 1. Science. 2024. PMID: 38301007
The miniature CRISPR-Cas12m effector binds DNA to block transcription.
Wu WY, Mohanraju P, Liao C, Adiego-Pérez B, Creutzburg SCA, Makarova KS, Keessen K, Lindeboom TA, Khan TS, Prinsen S, Joosten R, Yan WX, Migur A, Laffeber C, Scott DA, Lebbink JHG, Koonin EV, Beisel CL, van der Oost J. Wu WY, et al. Mol Cell. 2022 Dec 1;82(23):4487-4502.e7. doi: 10.1016/j.molcel.2022.11.003. Epub 2022 Nov 24. Mol Cell. 2022. PMID: 36427491 Free article.