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Page 1
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
Novotná K, Tenora L, Prchalová E, Paule J, Alt J, Veeravalli V, Lam J, Wu Y, Šnajdr I, Gori S, Mettu VS, Tsukamoto T, Majer P, Slusher BS, Rais R. Novotná K, et al. Among authors: prchalova e. J Med Chem. 2023 Nov 23;66(22):15493-15510. doi: 10.1021/acs.jmedchem.3c01681. Epub 2023 Nov 10. J Med Chem. 2023. PMID: 37949450 Free PMC article.
N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.
Nedelcovych MT, Tenora L, Kim BH, Kelschenbach J, Chao W, Hadas E, Jančařík A, Prchalová E, Zimmermann SC, Dash RP, Gadiano AJ, Garrett C, Furtmüller G, Oh B, Brandacher G, Alt J, Majer P, Volsky DJ, Rais R, Slusher BS. Nedelcovych MT, et al. Among authors: prchalova e. J Med Chem. 2017 Aug 24;60(16):7186-7198. doi: 10.1021/acs.jmedchem.7b00966. Epub 2017 Aug 14. J Med Chem. 2017. PMID: 28759224 Free PMC article.
N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.
Zimmermann SC, Tichý T, Vávra J, Dash RP, Slusher CE, Gadiano AJ, Wu Y, Jančařík A, Tenora L, Monincová L, Prchalová E, Riggins GJ, Majer P, Slusher BS, Rais R. Zimmermann SC, et al. Among authors: prchalova e. J Med Chem. 2018 May 10;61(9):3918-3929. doi: 10.1021/acs.jmedchem.7b01792. Epub 2018 Apr 19. J Med Chem. 2018. PMID: 29648826
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A. Zhu X, et al. Among authors: prchalova e. Neuropsychopharmacology. 2019 Mar;44(4):683-694. doi: 10.1038/s41386-018-0177-7. Epub 2018 Aug 13. Neuropsychopharmacology. 2019. PMID: 30127344 Free PMC article.
Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A. Zhu X, et al. Among authors: prchalova e. Neuropsychopharmacology. 2019 May;44(6):1178. doi: 10.1038/s41386-019-0354-3. Epub 2019 Mar 13. Neuropsychopharmacology. 2019. PMID: 30862949 Free PMC article.
Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists.
Prchalová E, Hin N, Thomas AG, Veeravalli V, Ng J, Alt J, Rais R, Rojas C, Li Z, Hihara H, Aoki M, Yoshizawa K, Nishioka T, Suzuki S, Kopajtic T, Chatrath S, Liu Q, Dong X, Slusher BS, Tsukamoto T. Prchalová E, et al. J Med Chem. 2019 Sep 26;62(18):8631-8641. doi: 10.1021/acs.jmedchem.9b01003. Epub 2019 Sep 9. J Med Chem. 2019. PMID: 31498617 Free PMC article.
Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.
Hollinger KR, Smith MD, Kirby LA, Prchalova E, Alt J, Rais R, Calabresi PA, Slusher BS. Hollinger KR, et al. Among authors: prchalova e. Neurol Neuroimmunol Neuroinflamm. 2019 Aug 29;6(6):e609. doi: 10.1212/NXI.0000000000000609. Print 2019 Nov. Neurol Neuroimmunol Neuroinflamm. 2019. PMID: 31467038 Free PMC article.
Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
Nedelcovych MT, Kim BH, Zhu X, Lovell LE, Manning AA, Kelschenbach J, Hadas E, Chao W, Prchalová E, Dash RP, Wu Y, Alt J, Thomas AG, Rais R, Kamiya A, Volsky DJ, Slusher BS. Nedelcovych MT, et al. Among authors: prchalova e. J Neuroimmune Pharmacol. 2019 Sep;14(3):391-400. doi: 10.1007/s11481-019-09859-w. Epub 2019 Jun 17. J Neuroimmune Pharmacol. 2019. PMID: 31209775 Free PMC article.
Correction to: Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
Nedelcovych MT, Kim BH, Zhu X, Lovell LE, Manning AA, Kelschenbach J, Hadas E, Chao W, Prchalová E, Dash RP, Wu Y, Alt J, Thomas AG, Rais R, Kamiya A, Volsky DJ, Slusher BS. Nedelcovych MT, et al. Among authors: prchalova e. J Neuroimmune Pharmacol. 2021 Sep;16(3):693. doi: 10.1007/s11481-021-09992-5. J Neuroimmune Pharmacol. 2021. PMID: 33914277 No abstract available.
21 results