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Page 1
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.
Porpaczy E, Tripolt S, Hoelbl-Kovacic A, Gisslinger B, Bago-Horvath Z, Casanova-Hevia E, Clappier E, Decker T, Fajmann S, Fux DA, Greiner G, Gueltekin S, Heller G, Herkner H, Hoermann G, Kiladjian JJ, Kolbe T, Kornauth C, Krauth MT, Kralovics R, Muellauer L, Mueller M, Prchal-Murphy M, Putz EM, Raffoux E, Schiefer AI, Schmetterer K, Schneckenleithner C, Simonitsch-Klupp I, Skrabs C, Sperr WR, Staber PB, Strobl B, Valent P, Jaeger U, Gisslinger H, Sexl V. Porpaczy E, et al. Blood. 2018 Aug 16;132(7):694-706. doi: 10.1182/blood-2017-10-810739. Epub 2018 Jun 14. Blood. 2018. PMID: 29907599 Free PMC article.
CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks.
Uras IZ, Maurer B, Nivarthi H, Jodl P, Kollmann K, Prchal-Murphy M, Milosevic Feenstra JD, Zojer M, Lagger S, Grausenburger R, Grabner B, Holly R, Kavirayani A, Bock C, Gisslinger H, Valent P, Kralovics R, Sexl V. Uras IZ, et al. Blood. 2019 Apr 11;133(15):1677-1690. doi: 10.1182/blood-2018-08-872648. Epub 2019 Jan 11. Blood. 2019. PMID: 30635286 Free PMC article.
CDK6 as a key regulator of hematopoietic and leukemic stem cell activation.
Scheicher R, Hoelbl-Kovacic A, Bellutti F, Tigan AS, Prchal-Murphy M, Heller G, Schneckenleithner C, Salazar-Roa M, Zöchbauer-Müller S, Zuber J, Malumbres M, Kollmann K, Sexl V. Scheicher R, et al. Blood. 2015 Jan 1;125(1):90-101. doi: 10.1182/blood-2014-06-584417. Epub 2014 Oct 23. Blood. 2015. PMID: 25342715 Free PMC article.
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.
Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T, Grausenburger R, Schiefer AI, Prchal-Murphy M, Chen D, Winkler S, Merkel O, Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, Prochazkova J, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A, Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L, Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R. Maurer B, et al. Haematologica. 2020 Jan 31;105(2):435-447. doi: 10.3324/haematol.2019.216986. Print 2020. Haematologica. 2020. PMID: 31123029 Free PMC article.
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Menzl I, Zhang T, Berger-Becvar A, Grausenburger R, Heller G, Prchal-Murphy M, Edlinger L, Knab VM, Uras IZ, Grundschober E, Bauer K, Roth M, Skucha A, Liu Y, Hatcher JM, Liang Y, Kwiatkowski NP, Fux D, Hoelbl-Kovacic A, Kubicek S, Melo JV, Valent P, Weichhart T, Grebien F, Zuber J, Gray NS, Sexl V. Menzl I, et al. Among authors: prchal murphy m. Nat Commun. 2019 Oct 18;10(1):4741. doi: 10.1038/s41467-019-12656-x. Nat Commun. 2019. PMID: 31628323 Free PMC article.
A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells.
Kollmann S, Grausenburger R, Klampfl T, Prchal-Murphy M, Bastl K, Pisa H, Knab VM, Brandstoetter T, Doma E, Sperr WR, Lagger S, Farlik M, Moriggl R, Valent P, Halbritter F, Kollmann K, Heller G, Maurer B, Sexl V. Kollmann S, et al. Among authors: prchal murphy m. Blood. 2021 Dec 9;138(23):2347-2359. doi: 10.1182/blood.2021010980. Blood. 2021. PMID: 34320169 Free PMC article.
In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity.
Prchal-Murphy M, Witalisz-Siepracka A, Bednarik KT, Putz EM, Gotthardt D, Meissl K, Sexl V, Müller M, Strobl B. Prchal-Murphy M, et al. Oncoimmunology. 2015 May 26;4(11):e1047579. doi: 10.1080/2162402X.2015.1047579. eCollection 2015 Nov. Oncoimmunology. 2015. PMID: 26451322 Free PMC article.
STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion.
Gotthardt D, Putz EM, Grundschober E, Prchal-Murphy M, Straka E, Kudweis P, Heller G, Bago-Horvath Z, Witalisz-Siepracka A, Cumaraswamy AA, Gunning PT, Strobl B, Müller M, Moriggl R, Stockmann C, Sexl V. Gotthardt D, et al. Cancer Discov. 2016 Apr;6(4):414-29. doi: 10.1158/2159-8290.CD-15-0732. Epub 2016 Feb 12. Cancer Discov. 2016. PMID: 26873347
Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity.
Putz EM, Majoros A, Gotthardt D, Prchal-Murphy M, Zebedin-Brandl EM, Fux DA, Schlattl A, Schreiber RD, Carotta S, Müller M, Gerner C, Decker T, Sexl V. Putz EM, et al. Oncoimmunology. 2016 May 19;5(9):e1186314. doi: 10.1080/2162402X.2016.1186314. eCollection 2016. Oncoimmunology. 2016. PMID: 27757297 Free PMC article.
35 results