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7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties.
Gorecki L, Muthna D, Merdita S, Andrs M, Kucera T, Havelek R, Muckova L, Kobrlova T, Soukup J, Krupa P, Prchal L, Soukup O, Roh J, Rezacova M, Korabecny J. Gorecki L, et al. Among authors: prchal l. Eur J Med Chem. 2022 Oct 5;240:114580. doi: 10.1016/j.ejmech.2022.114580. Epub 2022 Jun 30. Eur J Med Chem. 2022. PMID: 35793579
Donepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's Disease.
Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J. Mezeiova E, et al. Among authors: prchal l. Curr Alzheimer Res. 2019;16(9):772-800. doi: 10.2174/1567205016666190228122956. Curr Alzheimer Res. 2019. PMID: 30819078 Review.
A novel class of small molecule inhibitors with radioprotective properties.
Marek J, Tichy A, Havelek R, Seifrtova M, Filipova A, Andrejsova L, Kucera T, Prchal L, Muckova L, Rezacova M, Sinkorova Z, Pejchal J. Marek J, et al. Among authors: prchal l. Eur J Med Chem. 2020 Feb 1;187:111606. doi: 10.1016/j.ejmech.2019.111606. Epub 2020 Jan 1. Eur J Med Chem. 2020. PMID: 31901334
Substituted Piperazines as Novel Potential Radioprotective Agents.
Filipova A, Marek J, Havelek R, Pejchal J, Jelicova M, Cizkova J, Majorosova M, Muckova L, Kucera T, Prchal L, Psotka M, Zivna N, Koutova D, Sinkorova Z, Rezacova M, Tichy A. Filipova A, et al. Among authors: prchal l. Molecules. 2020 Jan 25;25(3):532. doi: 10.3390/molecules25030532. Molecules. 2020. PMID: 31991816 Free PMC article.
Wide-Antimicrobial Spectrum of Picolinium Salts.
Salajkova S, Benkova M, Marek J, Sleha R, Prchal L, Malinak D, Dolezal R, Sepčić K, Gunde-Cimerman N, Kuca K, Soukup O. Salajkova S, et al. Among authors: prchal l. Molecules. 2020 May 11;25(9):2254. doi: 10.3390/molecules25092254. Molecules. 2020. PMID: 32403238 Free PMC article.
The wide-spectrum antimicrobial effect of novel N-alkyl monoquaternary ammonium salts and their mixtures; the QSAR study against bacteria.
Soukup O, Benkova M, Dolezal R, Sleha R, Malinak D, Salajkova S, Markova A, Hympanova M, Prchal L, Ryskova L, Hobzova L, Sepčić K, Gunde-Cimerman N, Korabecny J, Jun D, Bostikova V, Bostik P, Marek J. Soukup O, et al. Among authors: prchal l. Eur J Med Chem. 2020 Nov 15;206:112584. doi: 10.1016/j.ejmech.2020.112584. Epub 2020 Jul 19. Eur J Med Chem. 2020. PMID: 32853858
46 results