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A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl.
Triller G, Vlachou EP, Hashemi H, van Straaten M, Zeelen JP, Kelemen Y, Baehr C, Marker CL, Ruf S, Svirina A, Chandra M, Urban K, Gkeka A, Kruse S, Baumann A, Miller AK, Bartel M, Pravetoni M, Stebbins CE, Papavasiliou FN, Verdi JP. Triller G, et al. Among authors: pravetoni m. Cell Rep. 2023 Feb 28;42(2):112049. doi: 10.1016/j.celrep.2023.112049. Epub 2023 Jan 30. Cell Rep. 2023. PMID: 36719797 Free PMC article.
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects.
Urban K, Gkeka A, Chandra M, Greiner D, Pollich S, Ruf S, Kelemen Y, Sundermann T, Pravetoni M, Baehr C, Stebbins CE, Papavasiliou FN, Verdi JP. Urban K, et al. Among authors: pravetoni m. Toxicol Lett. 2024 Apr 6;396:1-10. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print. Toxicol Lett. 2024. PMID: 38588756 Free article.
Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder: A Review.
Kiluk BD, Kleykamp BA, Comer SD, Griffiths RR, Huhn AS, Johnson MW, Kampman KM, Pravetoni M, Preston KL, Vandrey R, Bergeria CL, Bogenschutz MP, Brown RT, Dunn KE, Dworkin RH, Finan PH, Hendricks PS, Houtsmuller EJ, Kosten TR, Lee DC, Levin FR, McRae-Clark A, Raison CL, Rasmussen K, Turk DC, Weiss RD, Strain EC. Kiluk BD, et al. Among authors: pravetoni m. JAMA Psychiatry. 2023 Jan 1;80(1):84-92. doi: 10.1001/jamapsychiatry.2022.4020. JAMA Psychiatry. 2023. PMID: 36449315 Free PMC article. Review.
Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C).
Dick JK, Sangala JA, Krishna VD, Khaimraj A, Hamel L, Erickson SM, Hicks D, Soigner Y, Covill LE, Johnson A, Ehrhardt MJ, Ernste K, Brodin P, Koup RA, Khaitan A, Baehr C, Thielen BK, Henzler CM, Skipper C, Miller JS, Bryceson YT, Wu J, John CC, Panoskaltsis-Mortari A, Orioles A, Steiner ME, Cheeran MC, Pravetoni M, Hart GT. Dick JK, et al. Among authors: pravetoni m. bioRxiv [Preprint]. 2024 Apr 18:2024.04.16.589585. doi: 10.1101/2024.04.16.589585. bioRxiv. 2024. PMID: 38659969 Free PMC article. Preprint.
71 results