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N2FXm, a method for joint nuclear and cytoplasmic volume measurements, unravels the osmo-mechanical regulation of nuclear volume in mammalian cells.
Pennacchio FA, Poli A, Pramotton FM, Lavore S, Rancati I, Cinquanta M, Vorselen D, Prina E, Romano OM, Ferrari A, Piel M, Cosentino Lagomarsino M, Maiuri P. Pennacchio FA, et al. Among authors: pramotton fm. Nat Commun. 2024 Feb 7;15(1):1070. doi: 10.1038/s41467-024-45168-4. Nat Commun. 2024. PMID: 38326317 Free PMC article.
Accelerating the in vitro emulation of Alzheimer's disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model.
Ko EC, Spitz S, Pramotton FM, Barr OM, Xu C, Pavlou G, Zhang S, Tsai A, Maaser-Hecker A, Jorfi M, Choi SH, Tanzi RE, Kamm RD. Ko EC, et al. Among authors: pramotton fm. Front Bioeng Biotechnol. 2023 Oct 9;11:1251195. doi: 10.3389/fbioe.2023.1251195. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 37901842 Free PMC article.
PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1.
Poli A, Pennacchio FA, Ghisleni A, di Gennaro M, Lecacheur M, Nastały P, Crestani M, Pramotton FM, Iannelli F, Beznusenko G, Mironov AA, Panzetta V, Fusco S, Sheth B, Poulikakos D, Ferrari A, Gauthier N, Netti PA, Divecha N, Maiuri P. Poli A, et al. Among authors: pramotton fm. Nat Commun. 2023 Mar 14;14(1):1432. doi: 10.1038/s41467-023-37064-0. Nat Commun. 2023. PMID: 36918565 Free PMC article.
Patient's dermal fibroblasts as disease markers for visceral myopathy.
Viti F, Pramotton FM, Martufi M, Magrassi R, Pedemonte N, Nizzari M, Zanacchi FC, De Michele B, Alampi M, Zambito M, Santamaria G, Bajetto A, Sardar S, Tomati V, Gandullia P, Giampietro C, Florio T, Beltrame F, Vassalli M, Ceccherini I. Viti F, et al. Among authors: pramotton fm. Biomater Adv. 2023 May;148:213355. doi: 10.1016/j.bioadv.2023.213355. Epub 2023 Feb 23. Biomater Adv. 2023. PMID: 36893487 Free article.
Anisotropic topographies restore endothelial monolayer integrity and promote the proliferation of senescent endothelial cells.
Exarchos V, Neuber S, Meyborg H, Giampietro C, Chala N, Moimas S, Hinkov H, Kaufmann F, Pramotton FM, Krüger K, Rodriguez Cetina Biefer H, Cesarovic N, Poulikakos D, Falk V, Emmert MY, Ferrari A, Nazari-Shafti TZ. Exarchos V, et al. Among authors: pramotton fm. Front Cardiovasc Med. 2022 Oct 5;9:953582. doi: 10.3389/fcvm.2022.953582. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36277782 Free PMC article.
The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction.
Purushothaman D, Bianchi LF, Penkov D, Poli A, Li Q, Vermezovic J, Pramotton FM, Choudhary R, Pennacchio FA, Sommariva E, Foiani M, Gauthier N, Maiuri P, Blasi F. Purushothaman D, et al. Among authors: pramotton fm. Commun Biol. 2022 May 12;5(1):456. doi: 10.1038/s42003-022-03406-9. Commun Biol. 2022. PMID: 35550602 Free PMC article.
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