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Targeting Succinate Metabolism in Ischemia/Reperfusion Injury.
Kula-Alwar D, Prag HA, Krieg T. Kula-Alwar D, et al. Among authors: prag ha. Circulation. 2019 Dec 10;140(24):1968-1970. doi: 10.1161/CIRCULATIONAHA.119.042791. Epub 2019 Dec 9. Circulation. 2019. PMID: 31815541 Review. No abstract available.
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Martin JL, et al. Among authors: prag ha. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y. Nat Metab. 2019. PMID: 32395697 Free PMC article.
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, Hartley RC, Murphy MP, Krieg T. Prag HA, et al. Cardiovasc Drugs Ther. 2022 Feb;36(1):1-13. doi: 10.1007/s10557-020-07033-6. Epub 2020 Jul 9. Cardiovasc Drugs Ther. 2022. PMID: 32648168 Free PMC article.
Mechanism of succinate efflux upon reperfusion of the ischaemic heart.
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, Krieg T, Murphy MP, Aksentijević D. Prag HA, et al. Cardiovasc Res. 2021 Mar 21;117(4):1188-1201. doi: 10.1093/cvr/cvaa148. Cardiovasc Res. 2021. PMID: 32766828 Free PMC article.
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Park M, Nishimura T, Baeza-Garza CD, Caldwell ST, Pun PBL, Prag HA, Young T, Sauchanka O, Logan A, Forkink M, Gruszczyk AV, Prime TA, Arndt S, Naudi A, Pamplona R, Coughlan MT, Tate M, Ritchie RH, Caicci F, Kaludercic N, Di Lisa F, Smith RAJ, Hartley RC, Murphy MP, Krieg T. Park M, et al. Among authors: prag ha. Cardiovasc Drugs Ther. 2020 Dec;34(6):823-834. doi: 10.1007/s10557-020-07086-7. Epub 2020 Sep 26. Cardiovasc Drugs Ther. 2020. PMID: 32979176 Free PMC article.
Structural basis for a complex I mutation that blocks pathological ROS production.
Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C, James AM, Mottahedin A, Krieg T, Murphy MP, Hirst J. Yin Z, et al. Among authors: prag ha. Nat Commun. 2021 Jan 29;12(1):707. doi: 10.1038/s41467-021-20942-w. Nat Commun. 2021. PMID: 33514727 Free PMC article.
Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury.
Miljkovic JL, Burger N, Gawel JM, Mulvey JF, Norman AAI, Nishimura T, Tsujihata Y, Logan A, Sauchanka O, Caldwell ST, Morris JL, Prime TA, Warrington S, Prudent J, Bates GR, Aksentijević D, Prag HA, James AM, Krieg T, Hartley RC, Murphy MP. Miljkovic JL, et al. Among authors: prag ha. Redox Biol. 2022 Sep;55:102429. doi: 10.1016/j.redox.2022.102429. Epub 2022 Aug 5. Redox Biol. 2022. PMID: 35961099 Free PMC article.
34 results